Functional and structural amygdala - Anterior cingulate connectivity correlates with attentional bias to masked fearful faces
Functional and structural amygdala - Anterior cingulate connectivity correlates with attentional bias to masked fearful faces
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DOI：
10.1016/j.cortex.2013.07.008
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发表时间：
2013-10-01
期刊：
影响因子：
3.6
通讯作者：
Mujica-Parodi, Lilianne R.
中科院分区：
文献类型：
--
作者：
Carlson, Joshua M.;Cha, Jiook;Mujica-Parodi, Lilianne R.
对威胁的注意偏向与焦虑有因果关系。最近的研究将无意识的注意力偏向与威胁与杏仁核前扣带通路完整性的可变性联系起来，这揭示了焦虑行为前兆的神经解剖学基础。然而，杏仁核前环状带完整性的结构变异性在多大程度上与该通路内的功能连通性有关，以及这种功能连通性如何与注意偏差行为相关，仍然是这一难题的关键缺失部分。在15个个体中，我们使用扩散张量加权MRI（磁共振成像）测量了杏仁核前额叶通路的结构完整性，杏仁核种子与前扣带的内在功能连接，以及通过点探针任务对向后掩盖的恐惧面孔的注意偏倚。我们发现，对威胁的关注倾向越大，预示着钩状神经束完整性水平越高，杏仁核前扣带正向功能连通性越强，杏仁核与更广泛的社会感知网络（包括颞上沟、颞顶连接（TPJ）和体感皮层）的耦合程度越高。此外，钩状束完整性水平的提高与杏仁核前环状带内在功能连通性的提高相关。因此，高偏见个体在基础条件下表现出更高程度的杏仁核前扣带连通性，我们认为这使这些个体更容易将注意力集中在环境中的威胁信号上。Elsevier Ltd.出版。
An attentional bias to threat has been causally related to anxiety. Recent research has linked nonconscious attentional bias to threat with variability in the integrity of the amygdala anterior cingulate pathway, which sheds light on the neuroanatomical basis for a behavioral precursor to anxiety. However, the extent to which structural variability in amygdala anterior cing-ulate integrity relates to the functional connectivity within this pathway and how such functional connectivity may relate to attention bias behavior, remain critical missing pieces of the puzzle. In 15 individuals we measured the structural integrity of the amygdala prefrontal pathway with diffusion tensor-weighted MRI (magnetic resonance imaging), amygdala-seeded intrinsic functional connectivity to the anterior cingulate, and attentional bias toward backward masked fearful faces with a dotprobe task. We found that greater biases in attention to threat predicted greater levels of uncinate fasciculus integrity, greater positive amygdala anterior cingulate functional connectivity, and greater amygdala coupling with a broader social perception network including the superior temporal sulcus, tempoparietal junction (TPJ), and somatosensory cortex. Additionally, greater levels of uncinate fasciculus integrity correlated with greater levels of amygdala anterior cing-ulate intrinsic functional connectivity. Thus, high bias individuals displayed a heightened degree of amygdala anterior cingulate connectivity during basal conditions, which we believe predisposes these individuals to focus their attention on signals of threat within their environment. Published by Elsevier Ltd.