Tomato lycopene and its role in human health and chronic diseases.
Tomato lycopene and its role in human health and chronic diseases.
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发表时间：
2000-09
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通讯作者：
S. Agarwal;Akkinappally Venketeshwer Rao
中科院分区：
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作者：
S. Agarwal;Akkinappally Venketeshwer Rao
番茄红素是一种类胡萝卜素，存在于番茄、加工过的番茄制品和其他水果中。它是膳食类胡萝卜素中最有效的抗氧化剂之一。饮食中摄入番茄和含有番茄红素的番茄制品已被证明与降低患慢性疾病（如癌症和心血管疾病）的风险有关。血清和组织番茄红素水平已被发现与几种癌症的发病率呈负相关，包括乳腺癌和前列腺癌。虽然番茄红素的抗氧化特性被认为是其有益作用的主要原因，但越来越多的证据表明，其他机制也可能参与其中。在本文中，我们概述了番茄红素可能的作用机制，并回顾了目前对其在人类健康和疾病预防中的作用的认识。
Lycopene is a carotenoid that is present in tomatoes, processed tomato products and other fruits. It is one of the most potent antioxidants among dietary carotenoids. Dietary intake of tomatoes and tomato products containing lycopene has been shown to be associated with a decreased risk of chronic diseases, such as cancer and cardiovascular disease. Serum and tissue lycopene levels have been found to be inversely related to the incidence of several types of cancer, including breast cancer and prostate cancer. Although the antioxidant properties of lycopene are thought to be primarily responsible for its beneficial effects, evidence is accumulating to suggest that other mechanisms may also be involved. In this article we outline the possible mechanisms of action of lycopene and review the current understanding of its role in human health and disease prevention.