Interaction of hypertension and diabetes on renal function in black NIDDM subjects.
Interaction of hypertension and diabetes on renal function in black NIDDM subjects.
复制标题
高血压和糖尿病对黑人 NIDDM 受试者肾功能的相互作用。
DOI：
10.1038/ki.1995.235
复制
发表时间：
1995
影响因子：
19.6
通讯作者：
Lebovitz,HE
中科院分区：
文献类型：
--
作者：
Chaiken,RL;Palmisano,J;Norton,ME;Banerji,MA;Bard,M;Sachimechi,I;Behzadi,H;Lebovitz,HE
高血压和糖尿病对黑人NIDDM患者肾功能的影响我们研究了194例确诊为NIDDM的黑人受试者的肾功能，其病程从1个月到36年，以确定高血压和糖尿病对肾病的相互作用。通过同位素GFR和RPF研究以及血清肌酐评估肾功能。194例受试者中有117例有24小时尿白蛋白排泄（AER）。AER > 300 mg/24 h与NIDDM病程延长、GFR和RPF降低、血清Cr升高相关，且所有受试者均为高血压。AER 30 ~ 300 mg/24 h也与NIDDM持续时间较长相关，80%有高血压。当194名受试者根据NIDDM的持续时间和有无高血压进行分组时，血压正常的受试者肾功能正常。在高血压受试者中，NIDDM病程> 1年时GFR降低，NIDDM病程> 5年时RPF降低。在NIDDM > 10年的高血压受试者中，36%的肾功能受损（GFR < 80 ml/min/1.73 m2或血清肌酐> 1.4 mg/dl），75%的人有微量白蛋白尿或临床蛋白尿。在该组中，与在糖尿病之前或同时诊断为高血压的受试者相比，在糖尿病诊断后发生高血压的受试者可能有肾病证据：分别为20例中的17例（85%）和13例中的7例（54%）（P = 0.05）。这些数据提供了深入了解高血压和糖尿病之间的关系，在发展中的肾病黑人NIDDM个人。
Interaction of hypertension and diabetes on renal function in black NIDDM subjects. We studied renal function of 194 black subjects with duration of diagnosed NIDDM from 1 month to 36 years to determine the interaction of hypertension and diabetes on nephropathy. Renal function was assessed by isotopic GFR and RPF studies, and serum creatinine. One hundred seventeen of the 194 subjects had 24-hour urinary albumin excretion (AER). AER > 300 mg/24 h correlated with longer duration of NIDDM, decrease in GFR and RPF, and rise in serum Cr, and all subjects were hypertensive. AER 30 to 300 mg/24 h also correlated with a longer duration of NIDDM and 80% had hypertension. When 194 subjects were grouped according to duration of NIDDM and the presence or absence of hypertension, subjects who remained normotensive had normal renal function. In hypertensive subjects a decrease in GFR occurred with duration of NIDDM > 1 year and decrease in RPF with duration of NIDDM > 5 years. In hypertensive subjects with NIDDM > 10 years, 36% had impaired renal function (GFR < 80 ml/min/1.73 m2or serum creatinine > 1.4 mg/dl) and 75% had microalbuminuria or clinical proteinuria. Within this group, those subjects who developed hypertension after their diagnosis of diabetes were likely to have evidence of nephropathy as compared to those subjects whose hypertension was diagnosed prior to or simultaneous with their diabetes: 17 of 20 (85%) versus 7 of 13 (54%), respectively (P = 0.05). These data provide insight into the relationship between hypertension and diabetes in the development of nephropathy in black NIDDM individuals.