pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis isolates from northwestern Russia
pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis isolates from northwestern Russia
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DOI：
10.1128/aac.43.7.1764
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发表时间：
1999-07-01
影响因子：
4.9
通讯作者：
Viljanen, MK
中科院分区：
文献类型：
--
作者：
Marttila, HJ;Marjamäki, M;Viljanen, MK
分析了来自俄罗斯的36个吡嗪酰胺耐药和8个吡嗪酰胺敏感结核分枝杆菌分离株的pncA突变。31株（86.1%）耐药菌株在pncA或基因上游存在突变。在这项研究中发现的23种不同的突变中，有20种以前没有被描述过。pncA基因型与吡嗪酰胺酶活性和BACTEC 460药敏试验结果相关良好。
Thirty-six pyrazinamide-resistant and eight pyrazinamide-susceptible Mycobacterium tuberculosis isolates from Russia were analyzed for their pncA mutations. Thirty-one (86.1%) of the resistant isolates had a mutation either in pncA or upstream of the gene. Twenty of the 23 different mutations found in this study had not been described earlier. pncA genotype correlated well with pyrazinamidase activity and BACTEC 460 susceptibility test results.