Estrogen receptor α-negative breast cancer tissues express significant levels of estrogen-independent transcription factors, ERβ1 and ERβ5:: Potential molecular targets for chernoprevention
Estrogen receptor α-negative breast cancer tissues express significant levels of estrogen-independent transcription factors, ERβ1 and ERβ5:: Potential molecular targets for chernoprevention
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DOI：
10.1158/1078-0432.ccr-05-0728
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发表时间：
2005-10-15
影响因子：
11.5
通讯作者：
Liu, AY
中科院分区：
文献类型：
--
作者：
Poola, I;Fuqua, SAW;Liu, AY
我们研究了ER α阴性乳腺癌组织中两种雌激素受体β（ER β）亚型ER 131和ER 5的表达，它们独立于雌激素或生长因子激活基因转录。我们在此首次报道，ER α阴性组织表达显著水平的ER β 1和ER β 5，并且它们的表达水平与ER α阳性肿瘤中的水平没有差异。然而，两个种族组，非洲裔美国人和高加索人之间存在显着差异，因为前一组的患者表达更高水平的ER β 1和ER β 5，而不是ER α。这两个转录因子可能是设计治疗ER α阴性乳腺癌的化学预防药物的潜在分子靶点。
We have investigated the expression of two estrogen receptor beta (ER beta) isoforms, ERl3l and ER 5, which activate gene transcription independent of estrogen or growth factors, in ER alpha-negative breast cancer tissues. We report here, for the first time, that ER alpha-negative tissues express significant levels of ER beta 1 and ER beta 5, and their expression levels are not different from levels in ER alpha-positive tumors. However, significant differences exist between the two racial groups, African American and Caucasian, in that the patients from the former group express higher levels of ER beta 1 and ER beta 5 but not ER alpha. These two transcription factors could be potential molecular targets for designing chemopreventive drugs to treat ER alpha-negative breast cancers.