INFEROTEMPORAL-FRONTAL DISCONNECTION - THE UNCINATE FASCICLE AND VISUAL ASSOCIATIVE LEARNING IN MONKEYS
INFEROTEMPORAL-FRONTAL DISCONNECTION - THE UNCINATE FASCICLE AND VISUAL ASSOCIATIVE LEARNING IN MONKEYS
复制标题
DOI：
10.1111/j.1460-9568.1992.tb00157.x
复制
发表时间：
1992-12-01
影响因子：
3.4
通讯作者：
GAFFAN, D
中科院分区：
文献类型：
--
作者：
EACOTT, MJ;GAFFAN, D
我们报告了一系列的六个实验中，我们研究的行为影响断开颞叶下皮层的前额叶皮质在食蟹猴切片之间的直接皮质-皮质通路，钩束。在实验1中，双侧钩束节的猴子在学习视觉条件性问题时表现出明显的缺陷。实验2和3表明，这种缺陷是不是一个轻微的运动障碍，也不是视觉辨别障碍的结果。而实验4则表明，这种损害扩展到了视-视条件学习.相比之下，以下钩束猴的双边部分在视觉联想学习的其他两个任务中未受损：奖励-视觉联想任务（实验5），其中食物奖励的存在或不存在作为在两个视觉刺激之间正确选择的线索，以及时间-视觉联想任务（实验6），其中正确选择的线索是试验间隔的长度。因此，具有钩椎束部分的动物在学习基于其与食物奖励或其他非视觉线索的差异性关联在视觉刺激之间进行选择方面没有表现出损害，但是不能学习基于其与另一视觉刺激的差异性关联在视觉刺激之间进行选择。他们同样无法根据视觉线索在两种运动反应中做出选择。
We report a series of six experiments in which we examined the behavioural effects of disconnecting the inferior temporal cortex from the prefrontal cortex in cynomolgus monkeys by sectioning the direct cortico-cortical pathway between them, the uncinate fascicle. In experiment 1, monkeys with bilateral section of the uncinate fascicle showed a marked deficit in learning visuomotor conditional problems. Experiments 2 and 3 demonstrated that this deficit was not the result of a mild motor impairment, nor of a visual discrimination impairment. However, experiment 4 showed that the impairment extended to visual - visual conditional learning. In contrast, following bilateral section of the uncinate fascicle monkeys were unimpaired at two other tasks of visual associative learning: a reward - visual associative task (experiment 5), in which the presence or absence of a food reward served as a cue to the correct choice between two visual stimuli, and a time - visual associative task (experiment 6), in which the cue to the correct choice was the length of the intertrial interval. Thus, animals with uncinate fascicle section showed no impairment in learning to choose between visual stimuli based on their differential association with food reward or other non-visual cues, but were unable to learn to choose between visual stimuli based on their differential association with another visual stimulus. They were equally unable to choose between two motor responses on the basis of the visual cue.