Oral contraceptive use and risk of cancer--letter.
Oral contraceptive use and risk of cancer--letter.
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口服避孕药的使用和癌症风险——信。
DOI：
10.1158/1055-9965.epi-13-1164
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Weiss,NoelS
中科院分区：
文献类型：
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作者：
Weiss,NoelS
在对使用口服避孕药与几种癌症发病率之间可能存在关联的数据进行系统审查时，Gierisch 及其同事 (1) 系统地排除了 2000 年之前发表的研究。尽管这些早期研究可能代表了该主题的大多数证据，但作者试图“最大限度地提高使用与市场上类似的口服避孕药配方的受试者比例。”我认为，有理由询问激素避孕与癌症发病率之间是否存在因激素类型、剂量、给药途径等而异的关联，并且总结与这些问题有关的数据（在可获得的范围内）的分析将是一个很好的贡献。不幸的是，正如作者承认的那样，“研究发表年份”可能与激素暴露的任何特定特征只有微弱的相关性：毫无疑问，1999 年之后发表的研究中包含的许多女性会服用几年前就已经有的制剂。无论如何，不要假设前几年的数据不会提供信息，而是可以检查早期发布的数据和后来发布的数据，以发现所发现的任何关联的存在和规模可能存在的差异。我建议，流行病学研究中获得的大多数结果的“保质期”都在13年以上！
In their systematic review of data about the possible association between use of oral contraceptives and the incidence of several forms of cancer, Gierisch and colleagues (1) systematically excluded studies published before 2000. Although those earlier studies likely represent the majority of evidence on the topic, the authors sought" to maximize the proportion of subjects who used oral contraceptive formulations similar to those on the market." I believe it is reasonable to ask whether any association between hormonal contraception and cancer incidence differs by hormone type, dose, route of administration, etc., and analyses that sum up the data bearing on these questions (to the extent that they are available) would be a nice contribution. Unfortunately, as the authors acknowledge," year of study publication" may be only weakly correlated with any particular feature of hormone exposure: no doubt many women included in the studies published after 1999 would have taken preparations that had been available a number of years earlier. In any case, rather than assuming that data from prior years would not be informative, both earlier-published and later-published data could be examined for possible differences in the presence and size of any associations found. I suggest that most results obtained in epidemiologic studies have a" shelf life" of more than 13 years!