Neurofeedback-mediated self-regulation of the dopaminergic midbrain (Retracted Article)
Neurofeedback-mediated self-regulation of the dopaminergic midbrain (Retracted Article)
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DOI：
10.1016/j.neuroimage.2013.05.115
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发表时间：
2013-12-01
期刊：
影响因子：
5.7
通讯作者：
Gassert, Roger
中科院分区：
文献类型：
--
作者：
Sulzer, James;Sitaram, Ranganatha;Gassert, Roger
多巴胺能系统参与奖赏编码和强化学习。多巴胺能神经元从这个系统中的黑质/腹侧被盖区复合体（SN/VTA）火灾的反应意想不到的加强线索。这项研究的目的是调查个体是否可以获得对SN/VTA活动的自愿控制，从而潜在地增强多巴胺释放到目标大脑区域。神经反馈和心理意象被用来自我调节SN/VTA。实时功能磁共振成像（rtfMRI）提供了抽象的视觉反馈的SN/VTA活动，而受试者想象奖励的场景。记录皮肤电反应（SCR）作为情绪唤醒的测量。为了检查神经反馈的效果，受试者被分配到接收与SN/VTA活动成正比（n = 15，真实反馈）或成反比（n = 17，反向反馈）的反馈。两组受试者最初都能够在没有反馈的情况下上调SN/VTA活性。与基线相比，真实反馈提高了上调SN/VTA的能力，而反向反馈则没有。两组中额外的多巴胺能区域被激活。自我调节SN/VTA的能力与SCR的差异相关，这表明情绪唤醒和神经反馈性能之间的关联。这些发现表明，SN/VTA可以通过意象自愿激活，并且神经反馈可以进一步增强自愿激活。这一发现可能会为内源性控制多巴胺的非侵入性策略开辟道路。(C)2013 Elsevier Inc. All rights reserved.
The dopaminergic system is involved in reward encoding and reinforcement learning. Dopaminergic neurons from this system in the substantia nigra/ventral tegmental area complex (SN/VTA) fire in response to unexpected reinforcing cues. The goal of this study was to investigate whether individuals can gain voluntary control of SN/VTA activity, thereby potentially enhancing dopamine release to target brain regions. Neurofeedback and mental imagery were used to self-regulate the SN/VTA. Real-time functional magnetic resonance imaging (rtfMRI) provided abstract visual feedback of the SN/VTA activity while the subject imagined rewarding scenes. Skin conductance response (SCR) was recorded as a measure of emotional arousal. To examine the effect of neurofeedback, subjects were assigned to either receiving feedback directly proportional (n = 15, veridical feedback) or inversely proportional (n = 17, inverted feedback) to SN/VTA activity. Both groups of subjects were able to up-regulate SN/VTA activity initially without feedback. Veridical feedback improved the ability to up-regulate SN/VTA compared to baseline while inverted feedback did not. Additional dopaminergic regions were activated in both groups. The ability to self-regulate SN/VTA was differentially correlated with SCR depending on the group, suggesting an association between emotional arousal and neurofeedback performance. These findings indicate that SN/VTA can be voluntarily activated by imagery and voluntary activation is further enhanced by neurofeedback. The findings may lead the way towards a non-invasive strategy for endogenous control of dopamine. (C) 2013 Elsevier Inc. All rights reserved.