Resolving Inflammation by Targeting an Ancient Innate Immune Sensor with a Bacterial Metabolite.
Resolving Inflammation by Targeting an Ancient Innate Immune Sensor with a Bacterial Metabolite.
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通过用细菌代谢物靶向古老的先天免疫传感器来解决炎症。
DOI：
10.1016/j.jid.2017.07.815
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Johnston,Andrew
中科院分区：
文献类型：
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作者：
Johnston,Andrew
细菌、真菌和植物代谢物是用于药物发现的小分子的有前途的来源。史密斯等人。研究表明，tapinarof（一种细菌衍生的多酚）是一种芳基烃受体配体，可减弱炎症反应，并显示出治疗炎症性皮肤病的潜力。这项工作为不断增长的文献增添了新的内容，这些文献源于人们对发现和开发具有抗炎活性的新型小分子的新兴趣。
Bacterial, fungal, and plant metabolites are promising sources of small molecules for drug discovery. Smith et al. show that tapinarof, a bacteria-derived polyphenol, is an aryl hydrocarbon receptor ligand that attenuated inflammatory responses and shows therapeutic potential for inflammatory skin diseases. This work adds to the growing literature stemming from the renewed interest in the discovery and development of novel small molecules with anti-inflammatory activity.