Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts
Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts
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DOI：
10.1152/ajpcell.00154.2010
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发表时间：
2010-11-01
影响因子：
5.5
通讯作者：
Nelson, D. Michael
中科院分区：
文献类型：
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作者：
Chen, Baosheng;Longtine, Mark S.;Nelson, D. Michael
Chen B，Longtine MS，Sadovsky Y，纳尔逊DM.缺氧下调p53，但诱导细胞凋亡，并增强人合体滋养层细胞BAD的表达。美国生理学杂志细胞生理学299：C968-C976，2010年。首次发布于2010年9月1日; doi：10.1152/ajpcell。00154.2010.-缺氧通常在先兆子痫和宫内生长受限的胎盘功能障碍中起作用。我们以前表明，缺氧上调p53和增强细胞滋养层细胞的原代培养细胞凋亡。在这里，我们测试的假设，缺氧也诱导细胞凋亡的合胞体滋养层上调p53。将在52小时分化为合体滋养细胞的人细胞滋养细胞的原代培养物暴露于
Chen B, Longtine MS, Sadovsky Y, Nelson DM. Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts. Am J Physiol Cell Physiol 299: C968-C976, 2010. First published September 1, 2010; doi: 10.1152/ajpcell. 00154.2010.-Hypoxia is commonly assigned a role in the placental dysfunction characteristic of preeclampsia and intrauterine growth restriction. We previously showed that hypoxia upregulates p53 and enhances apoptosis in primary cultures of human cytotrophoblasts. Here we tested the hypothesis that hypoxia also induces apoptosis in syncytiotrophoblasts by upregulation of p53. Primary cultures of human cytotrophoblasts that had differentiated into syncytiotrophoblasts by 52 h were exposed for