CHANGE IN PHASE RELATIONSHIP BETWEEN SBP AND R-R INTERVAL DURING LOWER-BODY NEGATIVE-PRESSURE
CHANGE IN PHASE RELATIONSHIP BETWEEN SBP AND R-R INTERVAL DURING LOWER-BODY NEGATIVE-PRESSURE
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DOI：
10.1152/ajpheart.1995.268.4.h1688
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发表时间：
1995-04-01
影响因子：
4.8
通讯作者：
HUGHSON, RL
中科院分区：
文献类型：
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作者：
BLABER, AP;YAMAMOTO, Y;HUGHSON, RL
我们研究了收缩压（SEP）与R-R间期的逐搏相互作用（自发压力反射）依赖于R-R间期长度的假设。从8名健康男性中收集数据，同时通过施加下体负压（LBNP大于或等于-40 mmHg）使心率缓慢（R-R间期1，043 +/-34 ms）和加速（R-R间期804 +/-18 ms）。在SEP和R-R间期的时间序列数据中寻找R-R间期与SEP在相同（滞后0）、下一（滞后1）或下一（滞后2）搏动中变化的自发压力感受性反射序列，并通过交叉谱分析定量这种相位关系。在休息时，85%的自发性压力反射序列发生无滞后（滞后0）。使用LBNP，滞后0序列的数量显著减少（26%），而滞后1和滞后2序列增加（分别为10-26%和5- 29%）。交叉频谱相位也从静息时的-2.3 +/- 6.3度显著变化到LBNP期间的70.5 +/- 7.4度。这些数据支持了压力反射事件的滞后依赖于当前R-R间期的假设。
We have investigated the hypothesis that beat-by-beat interaction of systolic blood pressure (SEP) to R-R interval (the spontaneous baroreflex) is dependent on the length of the R-R interval. Data were collected from eight healthy men while heart rate was slow (R-R interval 1,043 +/- 34 ms) and accelerated (R-R interval 804 +/- 18 ms) by application of lower body negative pressure (LBNP greater than or equal to -40 mmHg). Time series data of SEP and R-R interval were searched for spontaneous baroreflex sequences in which R-R interval changed in the same (lag 0), next (lag 1), or next following (lag 2) beat as SEP. This phase relationship was also quantified by cross-spectral analysis. At rest, 85% of all spontaneous baroreflex sequences occurred with no lag (lag 0). With LBNP, there was a significant reduction in the number of lag 0 sequences (26%), whereas lag 1 and lag 2 sequences increased (10-26% and 5-29%, respectively). Cross-spectral phase also changed significantly from -2.3 +/- 6.3 degrees at rest to 70.5 +/- 7.4 degrees during LBNP. These data supported the hypothesis that the lag of a baroreflex event was dependent on the prevailing R-R interval.