Poly(ectoine) Hydrogels Resist Nonspecific Protein Adsorption
Poly(ectoine) Hydrogels Resist Nonspecific Protein Adsorption
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DOI：
10.1021/acs.langmuir.7b02434
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发表时间：
2017-10-24
期刊：
影响因子：
3.9
通讯作者：
Jiang, Shaoyi
中科院分区：
文献类型：
--
作者：
Jain, Priyesh;Hung, Hsiang-Chieh;Jiang, Shaoyi
防污两性离子材料的发展具有广泛的生物医学和工程应用。这项工作描述了基于天然存在的相容溶质四氢嘧啶的新型两性离子材料的设计和合成，已知四氢嘧啶具有额外的保护特性，甚至可以稳定整个细胞免受紫外线辐射或细胞毒素的影响。四氢嘧啶的这些特性和应用启发我们设计一种功能单体，其中含有四氢嘧啶的天然两性离子部分，可赋予防污性能，并含有用于聚合的甲基丙烯酸酯部分。甲基丙烯酸四氢嘧啶单体的合成路线简单、收率高，并通过核磁共振波谱和质谱表征。单体合成后，我们通过热聚合制备了聚（四氢嘧啶）水凝胶。测定了不同交联条件下聚四氢碱水凝胶的平衡含水量、交联度、机械强度和防污性能。聚（四氢嘧啶）水凝胶具有高度水合和优异的防污性能，可被认为是一种有前途的生物材料。
The development of nonfouling zwitterionic materials has a wide range of biomedical and engineering applications. This work delineates the design and synthesis of a new zwitterionic material based on a naturally occurring compatible solute, ectoine, which is known to possess additional protective properties that stabilize even whole cells against ultraviolet radiation or cytotoxins. These properties and applications of ectoine inspire us to design a functional monomer containing the natural zwitterion moiety of ectoine imparting nonfouling properties and the methacrylate moiety for polymerization. The synthesis route designed for the ectoine methacrylate monomer is simple with a high yield, which is characterized by nuclear magnetic resonance spectroscopy and mass spectrometry. After monomer synthesis, we have prepared a poly(ectoine) hydrogel via thermal polymerization. The equilibrium water content, degree of cross-linking, mechanical strength, and nonfouling properties are determined for polyectoine hydrogels with different cross-linking conditions. Poly(ectoine) hydrogels are shown to have highly hydrated and excellent nonfouling properties and can be considered to be a promising biomaterial.