Psychopathology risk transmission in children of parents with substance use disorders
Psychopathology risk transmission in children of parents with substance use disorders
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DOI：
10.1176/appi.ajp.161.4.685
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发表时间：
2004-04-01
影响因子：
17.7
通讯作者：
Vanyukov, M
中科院分区：
文献类型：
--
作者：
Clark, DB;Cornelius, J;Vanyukov, M
目的：父亲患有药物使用障碍的孩子患精神病理疾病的风险增加，包括品行障碍、注意缺陷多动障碍(ADHD)、严重抑郁障碍和焦虑障碍。本研究探讨了父母物质使用障碍和其他精神病理因素在儿童精神疾病风险传递中的不同影响。方法：研究对象为613个家庭中的1167名儿童(年龄6-14岁，其中62%为男性，38%为女性)。在这些家庭中，294个父亲有药物使用障碍(高风险组)，319个父亲没有药物使用障碍或其他精神障碍(低风险组)。在所有家庭中，父亲、母亲和孩子都被直接评估。结果：对于品行障碍、ADHD、重度抑郁和焦虑障碍，父母双方都有相应的精神障碍病史是子女特定精神障碍的主要预测因素。结论：这些结果支持儿童精神病理学的特异性亲子传播。
Objective: Children of fathers with substance use disorders are at increased risk for psychopathology, including conduct disorder, attention deficit hyperactivity disorder (ADHD), major depressive disorder, and anxiety disorders. This study examined the distinct influences of parent substance use disorder and other psychopathology in the transmission of the risk for psychopathology to their children.Method: The subjects were 1,167 children (ages 6-14 years; 62% were male, 38% were female) from 613 families recruited according to a high-risk paradigm. Of these families, 294 had fathers with a substance use disorder (high-risk group), and 319 had fathers without a substance use disorder or other mental disorder (low-risk group). In all families, father, mother, and children were directly assessed. Mixed-effects ordinal regression analyses controlled for the nested data structure.Results: For conduct disorder, ADHD, major depression, and anxiety disorders, the results indicated that the predominant predictor of specific mental disorders in offspring was a history of the corresponding disorders in both parents.Conclusions: These results support specific parent-child transmission for childhood psychopathology.