Osteopontin is involved in the initiation of cutaneous contact hypersensitivity by inducing langerhans and dendritic cell migration to lymph nodes
Osteopontin is involved in the initiation of cutaneous contact hypersensitivity by inducing langerhans and dendritic cell migration to lymph nodes
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DOI：
10.1084/jem.194.9.1219
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发表时间：
2001-11-05
影响因子：
15.3
通讯作者：
Simon, JC
中科院分区：
文献类型：
--
作者：
Weiss, JM;Renkl, AC;Simon, JC
骨桥蛋白（OPN）是一种趋化蛋白，可将免疫细胞吸引到炎症部位。过敏性皮肤接触性超敏反应（CHS）的致敏阶段需要朗格汉斯细胞/树突状细胞（LC/DC）从皮肤迁移到引流淋巴结。表征LC/DC迁移的OPN功能，我们发现半抗原致敏的皮肤和引流淋巴结中的OPN表达上调。OPN诱导趋化性LC/DC迁移，启动它们从表皮的迁移，并通过与CD 44和α v整联蛋白相互作用将LC/DC吸引到引流淋巴结。此外，OPN缺陷型小鼠具有显著降低的CHS应答，这与OPN缺陷型小鼠吸引LC/DC至引流淋巴结的所有受损能力相关。总之，OPN通过引导LC/DC从皮肤进入淋巴器官，在CHS的启动中是一个重要因素。
Osteopontin (OPN) is a chemotactic protein that attracts immune cells, to inflammatory sites. The sensitization phase of allergic cutaneous contact hypersensitivity (CHS) requires the migration of Langerhans cells/dendritic cells (LCs/DCs) from skin to draining lymph nodes. Characterizing OPN function for LC/DC migration we found upregulated OPN expression in hapten sensitized skin and draining lymph nodes. OPN induces chemotactic LC/DC migration, initiates their emigration from the epidermis, and attracts LCs/DCs to draining lymph nodes by interacting with CD44 and alphav integrin. Furthermore, OPN-deficient mice have a significantly reduced CHS response that correlates with all impaired ability of OPN-deficient mice to attract LCs/DCs to draining lymph nodes. In conclusion, OPN is an important factor in the initiation of CHS by guiding LCs/DCs from skin into lymphatic organs.