Cortical ensemble activity increasingly predicts behaviour outcomes during learning of a motor task
Cortical ensemble activity increasingly predicts behaviour outcomes during learning of a motor task
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DOI：
10.1038/35014604
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发表时间：
2000-06-01
期刊：
影响因子：
64.8
通讯作者：
Nicolelis, MAL
中科院分区：
文献类型：
--
作者：
Laubach, M;Wessberg, J;Nicolelis, MAL
当动物学习对不同刺激做出反应时，运动皮层活动的变化似乎伴随着这种学习并成为其基础（1-6）。然而，在运动学习的初始阶段，皮质运动区的修改的确切性质在很大程度上是未知的。在这里，我们解决这个问题，长期记录从位于大鼠运动皮层的神经元合奏，在整个期间所需的大鼠学习反应时间的任务。运动学习的表现是大鼠反应时间的变化减少，动物等待触发刺激的时间增加。这些行为的变化与我们的能力显着增加，以预测正确或不正确的结果，单次试验的基础上三个措施的神经元合奏活动：平均发射率，发射的时间模式，和相关的发射。这种预测的增加表明，随着任务的学习，感觉线索和运动之间的联系出现在运动皮层中。皮质整体活动的这种改变可能对运动任务的初始学习至关重要。
When an animal learns to make movements in response to different stimuli, changes in activity in the motor cortex seem to accompany and underlie this learning(1-6). The precise nature of modifications in cortical motor areas during the initial stages of motor learning, however, is largely unknown. Here we address this issue by chronically recording from neuronal ensembles located in the rat motor cortex, throughout the period required for rats to learn a reaction-time task. Motor learning was demonstrated by a decrease in the variance of the rats' reaction times and an increase in the time the animals were able to wait for a trigger stimulus. These behavioural changes were correlated with a significant increase in our ability to predict the correct or incorrect outcome of single trials based on three measures of neuronal ensemble activity: average firing rate, temporal patterns of firing, and correlated firing. This increase in prediction indicates that an association between sensory cues and movement emerged in the motor cortex as the task was learned. Such modifications in cortical ensemble activity may be critical for the initial learning of motor tasks.