Cannabis use during alcohol treatment is associated with alcohol-related problems one-year post-treatment
Cannabis use during alcohol treatment is associated with alcohol-related problems one-year post-treatment
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DOI：
10.1016/j.drugalcdep.2018.08.020
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发表时间：
2018-12-01
影响因子：
4.2
通讯作者：
Stout, Robert L.
中科院分区：
文献类型：
--
作者：
Subbaraman, Meenakshi S.;Metrik, Jane;Stout, Robert L.
背景：先前的研究表明，在治疗酒精使用障碍（AUD）期间使用大麻与较少的戒酒天数有关，尽管仅适用于使用大麻1-2次/月的人。在这里，我们通过评估AUD治疗期间大麻使用频率与治疗后酒精相关后果之间的关系来扩展先前的研究。方法：数据来自联合药物治疗和行为干预（COMBINE）研究，这是一项针对AUD治疗的大型美国随机对照试验。目前的分析包括206名大麻使用者和999名大麻戒断者，并比较使用大麻的人与在联合治疗期间戒断大麻的人之间的纵向饮酒数据。主要暴露是大麻使用的四分位数（Q1：治疗期间少于1次/月，Q2: 1-2次/月，Q3: 4-8次/月，Q4: 12次/月或更多），大麻戒断者作为参照组。结果是在治疗结束时和治疗后一年，通过饮酒者清单结果测量酒精相关问题。结果：与大麻戒断相比，治疗期间最频繁的使用与治疗后一年的身体后果相关的1.44倍。大麻使用与治疗后立即产生的身体后果无关，也与治疗后任何一个时间点的个人、人际、社会责任或冲动控制问题无关。结论：在接受AUD治疗的个体样本中，在治疗期间使用大麻12次/月或更多与酒精使用导致的身体后果发生率增加有关。在治疗AUD的同时也使用大麻的个体可能会从减少或停止使用大麻中受益，以避免与酒精相关的身体问题。
Background: Prior research shows that cannabis use during treatment for Alcohol Use Disorders (AUD) is related to fewer abstinent days from alcohol, although only among those who use cannabis 1-2x/month. Here we extend prior research by assessing the relationship between the frequency of cannabis use during AUD treatment and post-treatment alcohol-related consequences.Methods: Data come from the Combined Pharmacotherapies and Behavioral Interventions (COMBINE) Study, a large US randomized control trial of treatments for AUD. The current analyses include 206 cannabis users and 999 cannabis abstainers and compare longitudinal drinking data between those who used cannabis versus those who abstained during COMBINE treatment. The primary exposure was quartiles of cannabis use (Q1: less than 1x/month during treatment, Q2: 1-2x/month, Q3: 4-8x/month, Q4: 12x/month or more), with cannabis abstainers as the reference group. Outcomes were alcohol-related problems at the end of treatment and one-year post-treatment as measured by the Drinker Inventory Consequences.Results: Compared to cannabis abstinence, the most frequent use during treatment was related to 1.44 times as many physical consequences one-year post-treatment. Cannabis use was not related to physical consequences immediately after treatment, or to intrapersonal, interpersonal, social responsibility or impulse control problems at either post-treatment time point.Conclusions: In a sample of individuals in treatment for AUD, using cannabis 12x/month or more during treatment is associated with increased rates of physical consequences attributed to alcohol use. Individuals in treatment for AUD who also use cannabis might benefit from reducing or stopping cannabis use to avoid alcohol related physical problems.