Influence of higher BMI for hepatitis B- and C-related hepatocellular carcinomas
Influence of higher BMI for hepatitis B- and C-related hepatocellular carcinomas
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DOI：
10.1007/s00423-017-1589-2
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发表时间：
2017-08-01
影响因子：
2.3
通讯作者：
Ohdan, Hideki
中科院分区：
文献类型：
--
作者：
Hashimoto, Masakazu;Tashiro, Hirotaka;Ohdan, Hideki
虽然肥胖与肝细胞癌（HCC）的发展有关，但其对B型肝炎病毒（HBV）和丙型肝炎病毒（HCV）相关HCC患者手术结果的影响尚不清楚。其中，HBV相关HCC组（n = 125）和HCV相关HCC组（n = 426）根据是否存在体重指数（BMI）≥ 25 kg/m2进行细分。结果HBV相关性肝癌组术后5年生存率明显高于HCV相关性肝癌组。BMI ≥ 25 kg/m2组和不≥ 25 kg/m2组HBV相关HCC的5年总生存率分别为65%和85%。BMI ≥ 25 kg/m2和不≥ 25 kg/m2的HCV相关HCC患者的5年总生存率分别为75%和65%。BMI ≥ 25 kg/m2的HBV相关HCC组的预后显著差于BMI不≥ 25 kg/m2的HBV相关HCC组，而BMI ≥ 25 kg/m2的HCV相关HCC组的预后显著好于BMI不≥ 25 kg/m2的HCV相关HCC组。多因素分析显示，BMI ≥ 25 kg/m2分别是HBV相关和HCV相关HCC患者手术预后的正、负预后因素。结论BMI ≥ 25 kg/m2对HBV相关HCC患者手术预后有负、正影响。
Purpose Although obesity is associated with hepatocellular carcinoma (HCC) development, its impact on the surgical outcomes of patients with hepatitis B virus (HBV)-and hepatitis C virus (HCV)-related HCC remains unclear.Methods We retrospectively analyzed 714 patients with HCC who underwent curative hepatectomy. Among them, the HBV-related HCC group (n = 125) and HCV-related HCC group (n = 426) were subdivided according to the presence of body mass index (BMI)>= 25 kg/m(2). The surgical outcomes were compared.Results The 5-year overall survival rate after hepatectomy in the HBV-related HCC group was significantly better than that in the HCV-related HCC group. The 5-year overall survival rates of the HBV-related HCC with and without BMI >= 25 kg/m(2) groups were 65 and 85%, respectively. The 5-year overall survival rates in the HCV-related HCC with and without BMI >= 25 kg/m(2) groups were 75 and 65%, respectively. The HBV-related HCC with BMI >= 25 kg/m(2) groups had a significantly worse prognosis than the HBV-related HCC without BMI >= 25 kg/m(2) groups, while the HCV-related HCC with BMI >= 25 kg/m(2) groups had a significantly better prognosis than the HCV-related HCC without BMI >= 25 kg/m(2) groups. Multivariate analysis revealed that BMI >= 25 kg/m(2) was the positive and negative prognostic factor for the surgical outcomes of patients with HBV-and HCV-related HCC, respectively.Conclusions BMI >= 25 kg/m(2) negatively affected the surgical outcomes of patients with HBV-related HCC and positively affected those of patients with HCV-related HCC.