Association of seasonal allergic rhinitis is high in Graves' disease and low in painless thyroiditis
Association of seasonal allergic rhinitis is high in Graves' disease and low in painless thyroiditis
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DOI：
10.1089/105072503768499699
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发表时间：
2003-08-01
期刊：
影响因子：
6.6
通讯作者：
Nakata, Y
中科院分区：
文献类型：
--
作者：
Amino, N;Hidaka, Y;Nakata, Y
桥本甲状腺炎被认为是一种T辅助细胞1型（T(H)1）依赖性疾病，但Graves病是否以T辅助细胞2型（T(H)2）为主尚不清楚。T(H)1显性疾病不常见，T(H)2显性疾病常与过敏性疾病相关。我们检测了Graves病（n = 126）、无痛性甲状腺炎（n = 46）和桥本甲状腺炎（n = 88）患者对杉木花粉季节性变应性鼻炎（一种典型的T(H)2相关疾病）的患病率，并将其与健康对照组（n = 766）进行比较。除了桥本甲状腺炎患者的年龄较大外，患者组和健康对照组的性别和年龄分布没有差异。季节性变应性鼻炎的患病率在Graves病患者中显著高（42.9%,p < 0.05），在无痛性甲状腺炎患者中显著低（13.0%,p < 0.01），而桥本甲状腺炎患者（26.1%）与健康对照组（32.6%）差异无统计学意义（p < 0.01）。将无痛性甲状腺炎患者纳入桥本甲状腺炎组，季节性变应性鼻炎患病率为21.6%，与健康对照组比较差异有统计学意义（p < 0.05）。这些数据表明Graves病以T(H)2为主，无痛性甲状腺炎以T(H)1为主。我们的研究结果表明，从T(H)2向T(H)1免疫发生的转变可能对实现Graves病的早期缓解很重要。
Hashimoto's thyroiditis is thought to be a T-helper cell type 1 (T(H)1)-dependent disease, but it is not clear whether Graves' disease is T-helper cell type 2 (T(H)2)-predominant or not. T(H)1-predominant diseases are infrequently and T(H)2-predominant diseases are frequently associated with allergic diseases. We examined the prevalence of seasonal allergic rhinitis to Japanese cedar pollen, a typical T(H)2-associated disease, in patients with Graves' disease (n = 126), painless thyroiditis (n = 46) and Hashimoto's thyroiditis (n = 88), and compared them to healthy controls (n = 766). Gender and age distribution were not different among patient groups and healthy controls, except for the higher age of patients with Hashimoto's thyroiditis. The prevalence of seasonal allergic rhinitis was significantly high in patients with Graves' disease (42.9%, p < 0.05) and low in patients with painless thyroiditis (13.0%, p < 0.01) but was not different in patients with Hashimoto's thyroiditis (26.1%) compared to that of healthy controls (32.6%). When patients with painless thyroiditis were included in Hashimoto's thyroiditis group, the prevalence of seasonal allergic rhinitis was 21.6% and significantly different from that of healthy controls (p < 0.05). These data indicate that Graves' disease is T(H)2 predominant and painless thyroiditis is a T(H)1-predominant disease. Our findings suggest that the shift from T(H)2 toward T(H)1 immunogenesis may be important for achieving earlier remission of Graves' disease.