Microbe Profile: Akkermansia muciniphila: a conserved intestinal symbiont that acts as the gatekeeper of our mucosa
Microbe Profile: Akkermansia muciniphila: a conserved intestinal symbiont that acts as the gatekeeper of our mucosa
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DOI：
10.1099/mic.0.000444
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发表时间：
2017-05-01
期刊：
影响因子：
2.8
通讯作者：
de Vos, Willem M.
中科院分区：
文献类型：
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作者：
de Vos, Willem M.
嗜muciniphila是人类和许多其他动物肠道中的丰富居民。它是人类粪便中verrucomicrobia的唯一肠道代表，在患有肥胖、糖尿病和其他几种疾病的成年人中耗尽。A. muciniphila将肠道粘蛋白降解为主要的丙酸和乙酸，并与宿主共生，其特征是向免疫和代谢途径发出信号，启动营养链，并可能在宿主-微生物界面提供竞争性排斥。自从最近被发现以来，嗜muciniphila被越来越多地研究并被认为是一种真正的肠道共生体，在肠道中促进有益的相互作用。
Akkermansia muciniphila is an abundant inhabitant of the intestinal tract of humans and many other animals. It is the sole intestinal representative of the verrucomicrobia in human stools and depleted in adults suffering from obesity, diabetes and several other diseases. A. muciniphila degrades intestinal mucin into mainly propionic and acetic acid, and lives in symbiosis with its host, marked by signalling to immune and metabolic pathways, priming trophic chains and likely providing competitive exclusion at the host-microbe interface. Since its recent discovery, A. muciniphila has increasingly been studied and recognized as a true intestinal symbiont promoting beneficial interactions in the intestinal tract.