Fractional Exhaled Nitric Oxide (FeNO) and Spirometry as INdicators of Inhalation Exposure to Chemical Agents in Pathology Workers
Fractional Exhaled Nitric Oxide (FeNO) and Spirometry as INdicators of Inhalation Exposure to Chemical Agents in Pathology Workers
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呼出一氧化氮 (FeNO) 分数和肺活量测定法作为病理工作者吸入化学制剂暴露的指标
DOI：
10.1097/jom.0000000000000976
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发表时间：
2017
影响因子：
3.2
通讯作者：
Hioshi Inomata and Hajime Kurosawa
中科院分区：
文献类型：
--
作者：
Ritsuko Arakawa Suzuki;Toshiya Irokawa;Hiromasa Ogawa;Shinya Ohkouchi;Masao Tabata;Susumu Togashi;Takeshi Nakamura;Noriko Ohisa;Etsuhiro Nikkuni;Emiri Miura;Kaoru Yoshida;Hioshi Inomata and Hajime Kurosawa
目的：本研究的目的是检查是否可以使用呼出一氧化氮（FeNO）和肺功能测定作为指标，以评估不良健康影响的低浓度化学品吸入暴露，主要是甲醛。方法：33名受试者（病理技术人员）和30名对照（工人没有处理任何化学品在同一医院）参加了这项研究。结果：有哮喘史者FeNO明显升高（P< 0.05），用力肺活量（FVC）和第一秒用力呼气量（FEV 1）明显降低（P< 0.05）;结论：FeNO、FVC和FEV 1是低浓度化学品吸入暴露的有效健康效应指标。在医学领域，它被用作福尔马林消毒和保存。相反，FA被认为是呼吸敏化剂和环境污染物。长期暴露于FA可能导致支气管哮喘（BA）1、2上呼吸道炎症、3肺功能下降4和化学敏感性（CS）。5
Objective:The objective of this study was to examine whether fractional exhaled nitric oxide (FeNO) and spirometry can be used as indices to evaluate adverse health effects of low-concentrated chemical inhalation exposure, mainly to formaldehyde.Methods:Thirty-three subjects (pathology technicians) and 30 controls (workers without handling any chemicals in the same hospitals) participated in this study. All participants underwent FeNO measurement and spirometry before and after 5 days of work.Results:FeNO significantly increased in the subjects with a history of asthma (P< 0.05), whereas forced vital capacity (FVC) and forced expiratory volume in the first second (FEV1) decreased in the subjects (P< 0.05). Furthermore, work duration and pre-work levels of FEV1 in the subjects had a significant association.Conclusion:The results suggest that FeNO, FVC, and FEV1 represent effective health-effect indices of low-concentrated chemical inhalation exposure.BACKGROUNDFormaldehyde (FA) is a useful and important chemical in industry. In the medical field, it is used as formalin for disinfection and preservation. On the contrary, FA is recognized as a respiratory sensitizer and environmental pollutant. Chronic exposure to FA may cause bronchial asthma (BA) 1, 2 upper respiratory tract inflammation, 3 decreased pulmonary function, 4 and chemical sensitivity (CS). 5