Prognostic importance of fucosylated alpha-fetoprotein in hepatocellular carcinoma patients with low alpha-fetoprotein
Prognostic importance of fucosylated alpha-fetoprotein in hepatocellular carcinoma patients with low alpha-fetoprotein
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DOI：
10.1111/j.1440-1746.2011.06720.x
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发表时间：
2011-07-01
影响因子：
4.1
通讯作者：
Yamamoto, Kazuhide
中科院分区：
文献类型：
--
作者：
Nouso, Kazuhiro;Kobayashi, Yoshiyuki;Yamamoto, Kazuhide
背景和目的：岩藻糖基化甲胎蛋白（AFP-L3）是肝细胞癌（HCC）患者预后不良的标志物。但在低AFP（≤ 10%）组中，AFP-L3的测定比较困难。多因素分析显示，高天冬氨酸转氨酶（AST）（风险比[RR] = 3.24，95%置信区间[Cl] = 1.27-8.26），腹水的存在（RR = 3.44，95% CI = 1.22-9.34）、多发肿瘤数（RR = 3.06，95% CI = 1.33-7.17）、高AFP-L3（RR = 8.36，95% CI = 2.79-25.5）是生存的危险因素。高AFP-L3也是接受射频消融的肝癌患者生存的危险因素（P = 0.048）。结论：即使在低AFP的肝癌患者中，AFP-L3也是生存的强预后因素（
Background and Aim: Fucosylated alpha-fetoprotein (AFP-L3) is known to be a marker of poor prognosis in patients with hepatocellular carcinoma (HCC). However, it has been difficult to measure AFP-L3 under low AFP (= 10%) group. Multivariate analysis revealed that high aspartate aminotransferase (AST) (risk ratio [RR] = 3.24, 95% confidence interval [Cl] = 1.27-8.26), the presence of ascites (RR = 3.44, 95% Cl = 1.22-9.34), multiple tumor number (RR = 3.06, 95% CI = 1.33-7.17), and high AFP-L3 (RR = 8.36, 95% Cl = 2.79-25.5) were risk factors for survival. High AFP-L3 was also a risk factor for survival in HCC patients who received radiofrequency ablation (P = 0.048).Conclusions: AFP-L3 is a strong prognostic factor for survival even in HCC patients with low AFP (