TEMPERATURE REGULATION DURING WAKEFULNESS, SLEEP, AND HIBERNATION IN MARMOTS
TEMPERATURE REGULATION DURING WAKEFULNESS, SLEEP, AND HIBERNATION IN MARMOTS
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DOI：
10.1152/ajpregu.1978.235.1.r82
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发表时间：
1978-01-01
影响因子：
--
通讯作者：
HELLER, HC
中科院分区：
文献类型：
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作者：
FLORANT, GL;TURNER, BM;HELLER, HC
本文研究了3只适温黄腹旱獭（Marmota flaviventris）在清醒（W）、慢波睡眠（SWS）和异相睡眠（PS）时以及4只进入冬眠期的下丘脑温度阈值和代谢产热反应比例常数。下丘脑温度（Thy）的操纵与长期植入，水灌注热跨下丘脑。在实验过程中连续记录代谢产热率（MHP），测量为O2消耗量、环境温度（Ta）和Thy。唤醒状态是由皮层脑电图和颈背肌肌电图（EMG）记录定义的。在Ta为15 ℃时，对于清醒的适温土拨鼠，描述MHP对Thy（α MHP）降低的响应的比例常数为-1.10 W/kg/℃。C.在SWS期间，适温土拨鼠的α MHP下降到-0.55W/kg/℃。这些动物对低至34.5 ° C的Thy没有表现出代谢反应。C在PS中。在进入冬眠的动物中对Thy的操作揭示了持续下降的阈值Thy和α MHP。当α MHP表示为阈值的函数时，它具有2.1的温度系数。这种关系外推到在适温阈值Thy（37 ° C）下SWS的α MHP值。C）。体温的中枢神经调节器在冬眠者经历的整个体温范围（Tb）内持续工作。在冬眠期间获得的α MHP值外推到适温SWS值而不是适温清醒值的事实使冬眠是通常在SWS期间发生的体温调节的延伸的假设可信。
The threshold hypothalamic temperature and the proportionality constant for the metabolic heat production response were investigated in 3 euthermic marmots (Marmota flaviventris) during wakefulness (W), slow-wave sleep (SWS) and paradoxical sleep (PS), and in 4 marmots (Marmota flaviventris) during entrances into hibernation. Hypothalamic temperature (Thy) was manipulated with chronically implanted, water-perfused thermodes straddling the hypothalamus. Rate of metabolic heat production (MHP) measured as O2 consumption, ambient temperature (Ta) and Thy were continuously recorded during experiments. Arousal states were defined from recordings of the cortical EEG and the dorsal neck muscle electromyogram (EMG). The proportionality constant which describes the MHP response to a decrease in Thy (.alpha.MHP) was -1.10 W/kg per .degree.C for wakeful euthermic marmots at a Ta of 15.degree. C. During SWS, .alpha.MHP of euthermic marmots declined to -0.55 W/kg per .degree.C. These same animals showed no metabolic response to Thy as low as 34.5.degree. C during PS. Manipulations of Thy in animals entering hibernation revealed a continuously declining threshold Thy and .alpha.MHP. When .alpha.MHP was expressed as a function of threshold it had a temperature coefficient of 2.1. This relationship extrapolated to the .alpha.MHP value of SWS at a euthermic threshold Thy (37.degree. C). The central nervous regulator of body temperature is continuously operative over the entire range of body temperatures (Tb) experienced by the hibernator. The fact that values of .alpha.MHP obtained during hibernation extrapolate to euthermic SWS values rather than euthermic wakeful values lends credence to the hypothesis that hibernation is an extension of thermoregulatory adjustments which normally occur during SWS.