G-CSF is an essential regulator of neutrophil trafficking from the bone marrow to the blood
G-CSF is an essential regulator of neutrophil trafficking from the bone marrow to the blood
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DOI：
10.1016/s1074-7613(02)00424-7
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发表时间：
2002-10-01
期刊：
影响因子：
32.4
通讯作者：
Link, DC
中科院分区：
文献类型：
--
作者：
Semerad, CL;Liu, FL;Link, DC
中性粒细胞以一种有规律的方式从骨髓中释放出来，以维持血液中的动态平衡水平，并对包括感染在内的生理压力做出反应。我们发现在基础条件下，粒细胞集落刺激因子(G-CSF)是骨髓中性粒细胞释放的重要调节因子。G-CSF受体(G-CSFR)膜近端的87个氨基酸产生的非冗余信号足以介导这一反应。令人惊讶的是，中性粒细胞表面G-CSFR的表达既不是中性粒细胞从骨髓动员的必要条件，也不是充分必要条件，这表明G-CSF通过产生反式作用信号间接诱导中性粒细胞动员。有证据表明，骨髓中基质细胞衍生因子1的表达下调可能代表了这一信号。
Neutrophils are released from the bone marrow in a regulated fashion to maintain homeostatic levels in the blood and to respond to physiological stresses, including infection. We show that under basal conditions granulocyte colony-stimulating factor (G-CSF) is an essential regulator of neutrophil release from the bone marrow. Nonredundant signals generated by the membrane-proximal 87 amino acids of the G-CSF receptor (G-CSFR) are sufficient to mediate this response. Surprisingly, G-CSFR expression on neutrophils is neither necessary nor sufficient for their mobilization from the bone marrow, suggesting that G-CSF induces neutrophil mobilization indirectly through the generation of trans-acting signals. Evidence is provided suggesting that downregulation of stromal cell-derived factor 1 expression in the bone marrow may represent such a signal.