11B NMR/MRI Sensing of Copper(II) Ions In Vitro by the Decomposition of a Hybrid Compound of a nido-o-Carborane and a Metal Chelator
11B NMR/MRI Sensing of Copper(II) Ions In Vitro by the Decomposition of a Hybrid Compound of a nido-o-Carborane and a Metal Chelator
复制标题
通过 Nido-o-Carborane 和金属螯合剂的杂化化合物的分解对铜 (II) 离子进行 11B NMR/MRI 体外传感
DOI：
10.1002/ejic.201600346
复制
发表时间：
2016
影响因子：
2.3
通讯作者：
and Shin Aoki
中科院分区：
文献类型：
--
作者：
omohiro Tanaka;Rikita Araki;Takaomi Saido;Ryo Abe;and Shin Aoki
Cu2+与某些类型的生理和病理事件密切相关。因此，发展一种检测Cu2+的非侵入性方法对于了解其生物学作用及其与疾病的关系具有重要意义。在这里，我们报告了一种Cu2+特异的11B核磁共振/核磁共振探针的开发，其中包含一个螯合单元TriMEDA。该方法是基于生理条件下Cu2+对NIDO-O-Carborane的快速完全脱碳反应。
Cu2+is closely correlated with certain types of physiological and pathological events. Therefore, the development of a noninvasive methodology for detecting Cu2+is important for understanding its biological role and relationship with disease. Herein, we report on the development of a Cu2+‐specific11B NMR/MRI probe that contains a chelator unit, TriMEDA. The method is based on the rapid complete deboronation ofnido‐o‐carborane by Cu2+under physiological conditions.