Ontogeny of tissue and serum gastrin concentrations in fetal and neonatal sheep.
Ontogeny of tissue and serum gastrin concentrations in fetal and neonatal sheep.
复制标题
胎儿和新生羊组织和血清胃泌素浓度的个体发育。
DOI：
10.1152/ajpgi.1981.241.3.g235
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
MorrissJr,FH
中科院分区：
文献类型：
--
作者：
Lichtenberger,LM;Crandell,SS;Palma,PA;MorrissJr,FH
我们研究了围产期绵羊血清和组织胃泌素浓度的个体发生变化。用放射免疫分析和免疫组织化学方法检测胎儿和母体循环中留置导管所获得的血清中的血清胃泌素水平和组织胃泌素水平。胎儿血清胃泌素浓度直到妊娠第107天才能检测到，并显著增加到超过母体水平。新生儿血清激素水平持续升高，在出生后第4周达到高峰，在第4周后下降，与断奶一致。孕妇血清胃泌素浓度在妊娠期间没有变化，也与胎儿血清胃泌素水平无关。胎儿皱胃和十二指肠胃泌素浓度和皱胃G细胞数量随着妊娠期间胎儿血清激素水平的发育变化而增加。皱胃胃泌素浓度的发育增加与激素分子形式的变化无关。这些发现支持胎儿体内循环胃泌素起源于胎儿的假说。
We investigated the perinatal ontogenic changes in ovine serum and tissue gastrin concentration. Fetal and maternal serum gastrin levels in serums obtained from indwelling catheters in the fetal and maternal circulations and tissue gastrin levels were assessed by radioimmunoassay and immunohistochemistry. Fetal serum gastrin concentration was undetectable until the 107th day of gestation and significantly increased to levels surpassing maternal values. Neonatal serum hormone concentration continued to rise, reaching a peak during the 4th postnatal wk and decreasing after the 4th wk coincident with weaning. Maternal serum gastrin concentration did not vary during pregnancy and did not correlate with fetal serum gastrin levels. Fetal abomasal and duodenal gastrin concentrations and abomasal G-cell number increased in parallel with the developmental alterations in fetal serum hormone levels during gestation. The developmental increase in abomasal gastrin concentration was not associated with a shift in the molecular form of the hormone. These findings support the hypothesis that circulating gastrin in the fetus is of fetal origin.