Disease Tolerance during Viral-Bacterial Co-Infections.
Disease Tolerance during Viral-Bacterial Co-Infections.
复制标题
病毒 - 细菌共同感染期间的疾病耐受性。
DOI：
10.3390/v13122362
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发表时间：
2021-11-25
期刊：
影响因子：
--
通讯作者：
Metzger DW
中科院分区：
文献类型：
--
作者：
Barman TK;Metzger DW
除了宿主抵抗力之外，疾病耐受性已成为一种在病毒-细菌混合感染中生存的替代方式。疾病耐受性不仅在减少病原体负担方面发挥着重要作用，而且在维持组织完整性和控制器官损伤方面发挥着重要作用。常见的合并感染是流感病毒和肺炎链球菌之间观察到的协同作用，导致重复感染和致死。几种宿主细胞因子和细胞已显示出促进组织保护和损伤控制的前景，而其他细胞因子和细胞则诱导严重的免疫病理学，导致高发病率和死亡率。本综述的重点是描述宿主细胞因子和先天免疫细胞，它们介导疾病耐受性并导致宿主恢复稳态，并最终在病毒-细菌混合感染期间生存。
Disease tolerance has emerged as an alternative way, in addition to host resistance, to survive viral-bacterial co-infections. Disease tolerance plays an important role not in reducing pathogen burden, but in maintaining tissue integrity and controlling organ damage. A common co-infection is the synergy observed between influenza virus and Streptococcus pneumoniae that results in superinfection and lethality. Several host cytokines and cells have shown promise in promoting tissue protection and damage control while others induce severe immunopathology leading to high levels of morbidity and mortality. The focus of this review is to describe the host cytokines and innate immune cells that mediate disease tolerance and lead to a return to host homeostasis and ultimately, survival during viral-bacterial co-infection.
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DOI：
10.1165/ajrcmb.10.5.8179909
发表时间：
1994-05-01
影响因子：
6.4
作者：
BRADDING, P;ROBERTS, JA;HOLGATE, ST
通讯作者：
HOLGATE, ST
影响因子：
8
作者：
Califano D;Furuya Y;Roberts S;Avram D;McKenzie ANJ;Metzger DW
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Metzger DW
影响因子：
6.7
作者：
Carlson CM;Turpin EA;Moser LA;O'Brien KB;Cline TD;Jones JC;Tumpey TM;Katz JM;Kelley LA;Gauldie J;Schultz-Cherry S
通讯作者：
Schultz-Cherry S
影响因子：
3.3
作者：
Ayres, Janelle S.;Freitag, Nancy;Schneider, David S.
通讯作者：
Schneider, David S.
影响因子：
3.4
作者：
Busiello, I;Acquaviva, R;Zarrilli, R
通讯作者：
Zarrilli, R