Individuality and Transgenerational Inheritance of Social Dominance and Sex Pheromones in Isogenic Male Mice
Individuality and Transgenerational Inheritance of Social Dominance and Sex Pheromones in Isogenic Male Mice
复制标题
同基因雄性小鼠的个体性和社会支配地位和性信息素的跨代遗传
DOI：
10.1002/jez.b.22681
复制
发表时间：
2016-06-01
影响因子：
2.2
通讯作者：
Zhang, Jian-Xu
中科院分区：
文献类型：
--
作者：
Fang, Qi;Zhang, Yao-Hua;Zhang, Jian-Xu
近交系同基因小鼠的表型变异及其表观遗传调控一直是生物学家们感兴趣的问题。在这里，我们使用近交系C57 BL/6小鼠来研究社会优势和雄性信息素的个体差异和遗传，期望建立一个模型来研究这些性状进化的潜在表观遗传机制。我们使用了一个重复的男性-男性竞争范式，以形成稳定的优势-提交配对男性之间的关系，使上级或劣质的表现。雌性对占主导地位的雄性的尿液表现出嗅觉偏好，而对从属对手的尿液则表现出嗅觉偏好。气相色谱-质谱分析揭示了与优势相关或与上级质量相关的信息素实际上是夸大的雄性信息素组分（例如，E-β-法呢烯、十六醇和1-十六醇乙酸酯）。虽然统治和从属雄性的社会幼稚儿子成年后引起的女性吸引力相同，但前者可以在经历雄性竞争时控制后者，从而获得更多的女性吸引力。研究结果表明，群体优势或上级品质及其相关信息素是可遗传的，并通过攻击相关表观基因型和雄雄竞争之间的相互作用来表达。这表明，性选择性状的进化可以通过雌性的择偶决定和促进。行为和雄性信息素个体差异的表观遗传机制值得进一步研究。(C)2016 Wiley Periodicals，Inc.
Phenotypic variation and its epigenetic regulations within the inbred isogenic mice have long intrigued biologists. Here, we used inbred C57BL/6 mice to examine the individual differences and the inheritance of social dominance and male pheromones, expecting to create a model for studying the underlying epigenetic mechanisms for the evolution of these traits. We used a repeated male-male contest paradigm to form stable dominance-submission relationships between paired males and make superior or inferior quality manifest. Females showed olfactory preferences for the urine of dominant males to that of subordinate opponents. Gas chromatography-mass spectrometer analysis revealed that dominance-related or superior quality related pheromones were actually exaggerated male pheromone components (e.g., E-beta-farnesene, hexadecanol, and 1-hexadecanol acetate) of preputial gland origin. Although the socially naive sons of both dominant and subordinate males elicited the same female attraction when reaching adulthood, the former could dominated over the latter during undergoing the male-male competition and then gained more attraction of females. Our results demonstrated that social dominance or superior quality and the related pheromones were heritable and could be expressed through the interaction between aggression-related epigenotypes and male-male contests. It suggested that the evolution of sexually selected traits could be epigenetically determined and promoted through female mate choice. The epigenetic mechanisms driving the individual differences in behavior and male pheromones deserve further studies. (C) 2016 Wiley Periodicals, Inc.