Rapid dissolution of gallstones by methyl tert-butyl ether. Preliminary observations.
Rapid dissolution of gallstones by methyl tert-butyl ether. Preliminary observations.
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甲基叔丁基醚快速溶解胆结石。
DOI：
10.1056/nejm198501243120406
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
J. Thistle
中科院分区：
文献类型：
--
作者：
M. Allen;T. Borody;Thomas F. Bugliosi;G. May;N. LaRusso;J. Thistle
尽管手术是治疗胆石症的一种历史悠久的方法，但在过去的十年里，胆囊或胆管结石的溶解越来越受到关注。许多溶剂已通过口服或直接输注到胆道系统中进行给药。1然而，结石溶解速度缓慢或令人烦恼的副作用限制了这些药物的临床应用。Chenodiol和熊去氧胆酸通常需要一到三年的时间才能达到完全溶解结石的效果。目前优选的直接溶解剂，单辛酸甘油酯，通常需要3至21天来溶解胆固醇导管结石。
ALTHOUGH surgery has been the time-honored treatment for cholelithiasis, dissolution of gallbladder or bile-duct stones has received increasing interest in the past decade. Numerous solvents have been administered either orally or by direct infusion into the biliary system.1 However, a slow rate of stone dissolution or troublesome side effects have restricted the clinical utility of these agents. Chenodiol and ursodeoxycholic acid usually require one to three years to achieve complete stone dissolution when they are effective. The currently preferred agent for direct dissolution, mono-octanoin, usually requires 3 to 21 days to dissolve cholesterol duct stones.2 3 4 5 6 A much more useful approach . . .