Scurvy in an alcohol-dependent patient with a severely unbalanced diet
Scurvy in an alcohol-dependent patient with a severely unbalanced diet
复制标题
饮食严重不均衡的酒精依赖患者患坏血病
DOI：
10.1111/pcn.12109
复制
发表时间：
2014
影响因子：
11.9
通讯作者：
Tetsuo Shimizu
中科院分区：
文献类型：
--
作者：
Masahiro Takeshima;Masaru Echizenya;Yoshiyuki Inomata;Tetsuo Shimizu
我们饶有兴趣地阅读了Poletti等人的研究，他们调查了帕金森病（PD）早期或中度/晚期患者以及一组健康受试者（HC）的心理理论（ToM）的情感成分。1 Poletti等人发现，与HC相比，PD患者的情感ToM受损，而在PD组中所有显著不同的变量（年龄、运动残疾、一般认知能力）进行协变后，未发现早期和中度患者之间存在显著差异。1以前的研究已经产生了对比的结果，在早期PD的情感心理理论的损害。两项研究未报告PD和HC之间的显著差异，2，3而Tsuruya等人发现情感ToM受损。4与后一项研究结果一致，我们最近报道了早期PD患者的情感和认知ToM功能障碍; 5此外，情感ToM改变与冷漠显著相关，这是一种与PD患者非运动性额叶皮层下回路功能障碍相关的行为障碍。6这些观察结果表明，眶额边缘回路的功能障碍可能导致早期PD中情感ToM的受损。Poletti等人的研究与我们的研究在方法上存在一些差异：Poletti等人使用主要基于视觉情感识别的非语言任务（阅读眼睛中的心灵任务）1评估情感心理理论，而我们使用两个语言任务（情感归因任务和心理理论高级测试）更具体地挖掘将情感或意图归因于他人的能力。[5]此外，我们将早期PD患者和HC患者的人口统计学和认知变量进行了密切匹配，因此我们可以直接比较这两组，而无需依赖Poletti等人所采用的同样有问题的统计程序。1
WE HAVE READ with interest the study in which Poletti et al. investigated the affective component of theory of mind (ToM) in patients at early or moderate/advanced stages of Parkinson’s disease (PD), and in a group of healthy subjects (HC). 1 Poletti et al. found impaired affective ToM in PD patients in comparison to HC, while no significant difference between early and moderate patients was found after covarying for all variables significantly different in the PD groups (age, motor disability, general cognitive abilities). 1 Previous studies have produced contrasting findings on impairment of the affective ToM in early PD. Two studies did not report significant differences between PD and HC, 2, 3 whereas Tsuruya et al. found impaired affective ToM. 4 In line with the latter findings, we recently reported dysfunction of both the affective and the cognitive ToM in early PD patients; 5 moreover, altered affective ToM was significantly associated with apathy, a behavioral disturbance associated with dysfunction of non-motor fronto-subcortical circuits in PD. 6 These observations would suggest that a dysfunction of orbitofrontal–limbic circuits may contribute to an impairment of the affective ToM in early PD. There are several methodological differences between the Poletti et al. study and ours: Poletti et al. assessed affective ToM using a non-verbal task mainly based on visual emotion recognition (Reading the Mind in the Eyes Task), 1 whereas we used two verbal tasks (the Emotion Attribution Task, and the Advanced Test of ToM) more specifically tapping the ability to attribute emotions or intentions to others. 5 Moreover, we closely matched early PD patients and HC for demographic and cognitive variables, so that we could directly compare these two groups without relying on the same problematic statistical procedure that Poletti et al. had to adopt. 1