METHAMPHETAMINE-INDUCED INSULIN RELEASE
METHAMPHETAMINE-INDUCED INSULIN RELEASE
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DOI：
10.1126/science.174.4004.66
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发表时间：
1971-01-01
期刊：
影响因子：
56.9
通讯作者：
SCHANBERG, SM
中科院分区：
文献类型：
--
作者：
MCMAHON, EM;ANDERSEN, DK;SCHANBERG, SM
给大鼠和小鼠施用甲基苯丙胺或苯丙胺会导致可免疫测定的血浆胰岛素水平迅速增加，这并非归因于高血糖。在小鼠中，胰岛素释放后始终会出现严重的低血糖，而在大鼠中，这种反应是可变的。体外研究表明，甲基苯丙胺直接作用于胰腺，从而释放胰岛素。
Administration of methamphetamine or amphetamine to rats and mice produces a rapid increase in the level of immunoassayable plasma insulin not attributable to hyperglycemia. While in the mouse this release of insulin is followed consistently by a profound hypoglycemia, in the rat this response is variable. Studies in vitro demonstrate that insulin is released by a direct effect of methamphetamine on the pancreas.