Detection of carotid adventitial vasa vasorum and plaque vascularization with ultrasound cadence contrast pulse sequencing technique and echo-contrast agent
Detection of carotid adventitial vasa vasorum and plaque vascularization with ultrasound cadence contrast pulse sequencing technique and echo-contrast agent
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DOI：
10.1161/strokeaha.107.487918
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发表时间：
2007-10-01
期刊：
影响因子：
8.3
通讯作者：
Lenzi, Gian Luigi
中科院分区：
文献类型：
--
作者：
Vicenzini, Edoardo;Giannoni, Maria Fabrizia;Lenzi, Gian Luigi
背景和目的：血管外膜小血管和斑块血管化已被确定为脑和心血管患者不稳定动脉粥样硬化病变的预测因子。超声造影剂可提供可靠的组织灌注和微循环信息。方法对23例颈动脉斑块不同程度狭窄和回声强度的患者进行颈动脉声学造影双功扫描，结果在纤维和纤维脂肪组织中发现斑块血管化，而在钙化、坏死和出血组织中未发现。不断地，观察到一个小血管溃疡。结论-颈动脉造影超声成像似乎是一种新兴的技术，用于识别斑块血管生成。需要进一步的研究来阐明斑块血管生成在评估脑血管风险中的作用，并监测旨在斑块重塑的疗法的效果。
Background and Purpose - Adventitial vasa vasorum and plaque vascularization have been established as predictors of unstable atheromasic lesions in cerebro- and cardiovascular patients. Ultrasound contrast agents provide reliable information on tissue perfusion and microcirculation. We used contrast ultrasound duplex scanning to identify carotid plaque vascularization.Methods - Contrast carotid duplex scanning was performed in 23 patients with plaques of different degree of stenosis and echogenicity.Results - Plaque vascularization was detected in the fibrous and fibro-fatty tissue and not observed in the calcific nor in the necrotic and hemorrhagic tissue. Constantly, a small vessel was observed under ulcerations.Conclusions - Carotid contrast ultrasound imaging appears to be an emerging technique for identifying plaque angiogenesis. Further studies are needed to clarify the role of plaque angiogenesis for assessing cerebrovascular risk and to monitor effects of therapies aimed to plaque remodelling.