In situ production and renewal of biocatalytic coatings for use in enzymatic reactive distillation
In situ production and renewal of biocatalytic coatings for use in enzymatic reactive distillation
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DOI：
10.1016/j.cej.2016.08.031
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发表时间：
2016-12-15
影响因子：
15.1
通讯作者：
Smirnova, Irina
中科院分区：
文献类型：
--
作者：
Heils, Rene;Hu, Xihua;Smirnova, Irina
反应蒸馏是化学工业中最成熟的一体化分离工艺之一，用于生产例如：燃料添加剂。最近，酶在反应蒸馏塔中的可行性得到了证明，这可能将范围扩展到与手性产物进行更具选择性的反应。然而，酶的低热稳定性需要更频繁的催化剂更换，由于催化结构的成本非常高且工艺关闭时间长，这通常是该工艺的淘汰标准。在这项工作中，提出了一种规整填料上生物催化涂层的原位生产方法，该方法能够就地生产和更新催化结构，即无需拆卸塔内部构件。通过用反应酶/硅溶胶淹没柱子，纱布规整填料被均匀的凝胶层覆盖，干燥后形成含有固定化酶的催化涂层。原位方法可以帮助简化反应蒸馏过程中的催化剂更换，并且还可以在反应段中改变催化剂的数量和位置，这些是反应蒸馏过程设计阶段的重要工艺参数。 (C) 2016 Elsevier B.V. 保留所有权利。
Reactive distillation is one of the most well-established integrative separation processes in chemical industry which is used for the production of e.g. fuel additives. Recently, the feasibility of enzymes in reactive distillation columns was demonstrated, which possibly extends the scope towards more selective reactions with chiral products. However, the low thermal stability of enzymes necessitates a more frequent catalyst exchange which is usually a knock-out criterion for this process due to very high costs of catalytic structures and long process shut down times. In this work, an in situ production method for biocatalytic coatings on structured packings is presented which enables production and renewal of the catalytic structures in place, i.e. without disassembly of the column internals. By flooding the column with reacting enzyme/silica-sol, gauze structured packings are covered with a uniform layer of gel, which after drying results in a catalytic coating containing immobilized enzymes. The in situ method could help simplify the catalyst exchange in reactive distillation processes and furthermore allows changes in the reactive section in terms of amount and position of the catalyst which are important process parameters in the design phase of reactive distillation processes. (C) 2016 Elsevier B.V. All rights reserved.