High-fat diet exposure increases dopamine D2 receptor and decreases dopamine transporter receptor binding density in the nucleus accumbens and caudate putamen of mice
High-fat diet exposure increases dopamine D2 receptor and decreases dopamine transporter receptor binding density in the nucleus accumbens and caudate putamen of mice
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DOI：
10.1007/s11064-007-9483-x
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发表时间：
2008-03-01
影响因子：
4.4
通讯作者：
Huang, Xu-Feng
中科院分区：
文献类型：
--
作者：
South, Timothy;Huang, Xu-Feng
该实验检测了喂食高脂或低脂饮食二十天的小鼠以及喂食二十天高脂饮食然后改为低脂饮食 1 天和 7 天的小鼠的多巴胺 D2 受体及其转运蛋白 (DAT) 密度。定量放射自显影显示，与低脂饮食相比，20天的高脂饮食摄入显着增加了尾壳核背侧和腹侧的D2受体和DAT密度降低（D2分别为32%和35%，DAT分别为33.3%和28.8%）。高脂肪喂养还增加了伏核壳中 D2 的结合 (36%)。将饮食从高脂饮食逆转为低脂饮食后，D2 受体和 DAT 密度保持不变。高脂肪饮食诱导的 D2 受体增加和 DAT 结合减少可能是由于响应正能量平衡而对多巴胺能活动进行防御性控制而发生的。
This experiment examined dopamine D2 receptor and its transporter (DAT) density in mice fed a high-fat or low-fat diet for twenty days as well as fed twenty days of high-fat diet then changed to low-fat diet for one and seven days. Quantitative autoradiography revealed that twenty days of high-fat diet consumption significantly increased D2 receptor and decreased DAT density in the dorsal and ventral parts of the caudal caudate putamen (D2: 32% and 35% respectively, DAT: 33.3% and 28.8% respectively) compared with low-fat diet. High-fat feeding also increased D2 binding in the nucleus accumbens shell (36%). D2 receptor and DAT density remained unchanged following reversal of the diets from high-fat to low-fat diet. The high-fat diet induced increase of D2 receptor and decrease of DAT binding may have occurred due to defensive control over dopaminergic activity in response to a positive energy balance.