Exchange of dominant lymphoid cell clones in a patient with adult T-cell leukemia/lymphoma.
Exchange of dominant lymphoid cell clones in a patient with adult T-cell leukemia/lymphoma.
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成人 T 细胞白血病/淋巴瘤患者中优势淋巴细胞克隆的交换。
DOI：
10.2340/00015555704952
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发表时间：
1990
影响因子：
3.6
通讯作者：
M. Yamada
中科院分区：
文献类型：
--
作者：
K. Iwatsuki;F. Inoue;M. Takigawa;G. Iemoto;T. Nagatani;H. Nakajima;M. Yamada
我们进行了一项基因型研究淋巴细胞从成人T细胞白血病（ATL）患者。在原发性皮肤肿瘤中检测到人类嗜淋巴细胞病毒1型（HTLV-1）感染的辅助性T细胞的克隆性增殖，而在外周血中未观察到病毒感染的淋巴细胞的克隆性。然而，在强化化疗后，我们在取自外周血的不同样本中检测到两种基因型不同的HTLV-1感染淋巴细胞克隆的存在。这些数据表明，在ATL的临床过程中，占主导地位的肿瘤克隆的交换，这表明在许多的HTLV-1感染的T细胞的剧目中的某个克隆具有白血病发生的能力，而不是原发性肿瘤细胞的可能性。
We performed a genotypic study on lymphoid cells from a patient with adult T-cell leukemia (ATL). Clonal proliferation of human lymphotropic virus type-1(HTLV-1)-infected helper T-cells was detected in the primary skin tumors, while no clonality of the virus-infected lymphocytes was observed in the peripheral blood. Following intensive chemotherapy, however, we detected the presence of two genotypically different HTLV-1-infected lymphocyte clones in different samples taken from the peripheral blood. These data demonstrated the exchange of the dominant neoplastic clone in the clinical course of ATL, suggesting the possibility that a certain clone among many repertoires of HTLV-1-infected T-cells has a capability of leukemogenesis, instead of the primary tumour cells.