ANTIGONADAL EFFECTS OF TIMED MELATONIN INFUSION IN PINEALECTOMIZED MALE DJUNGARIAN HAMSTERS (PHODOPUS-SUNGORUS-SUNGORUS) - DURATION IS THE CRITICAL PARAMETER
ANTIGONADAL EFFECTS OF TIMED MELATONIN INFUSION IN PINEALECTOMIZED MALE DJUNGARIAN HAMSTERS (PHODOPUS-SUNGORUS-SUNGORUS) - DURATION IS THE CRITICAL PARAMETER
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DOI：
10.1210/endo-113-4-1261
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发表时间：
1983-01-01
期刊：
影响因子：
4.8
通讯作者：
GOLDMAN, BD
中科院分区：
文献类型：
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作者：
CARTER, DS;GOLDMAN, BD
为了确定松果体褪黑激素分泌的日/夜模式的哪个参数是Djungarian仓鼠中信号传导昼长信息的关键组分，开发了一种方法，用于给予定时的s.c.褪黑激素输注在松果体切除的少年男性。当每天给药12小时时，低至10 ng褪黑激素（14 pg/min）在12天内持续诱导睾丸退化。然而，每天输注10 ng褪黑激素4或6 h并不抑制性腺发育。这些输注对生殖系统的影响并不取决于一天中给予褪黑激素的时间。在补充实验中，确定了诱导睾丸退化的最小每日输注持续时间和临界日照长度。输注的临界长度（7-8小时）与在临界暗相期间褪黑激素分泌的估计持续时间密切一致。褪黑激素显然介导的短日照暴露在Djungarian仓鼠的松果体抗性腺作用。持续时间显然是夜间褪黑激素释放的特征，这对于该物种的光周期时间测量是最重要的。
To determine which parameter of the day/night pattern of pineal melatonin secretion is the critical component signaling daylength information in the Djungarian hamster, a method was developed for giving timed s.c. melatonin infusions in pinealectomized juvenile males. When given for 12 h daily, as little as 10 ng melatonin (14 pg/min) consistently induced testicular regression within 12 days. However, 10 ng melatonin infused for 4 or 6 h daily did not inhibit gonadal development. The effects of these infusions on the reproductive system did not depend on the time of day at which melatonin was administered. In complementary experiments, the minimal daily infusion duration and the critical daylength for induction of testicular regression were determined. The critical length of infusion (7-8 h) was in close agreement with the estimated duration of melatonin secretion during the critical scotophase. Melatonin apparently mediates the pineal-antigonadal effects of short day exposure in the Djungarian hamster. Duration apparently is the feature of nighttime melatonin release that is most important for photoperiodic time measurement in this species.