Molecular container assembly capable of controlling binding and release of its guest molecules: Reversible encapsulation of organic molecules in sodium ion complexed cucurbituril
Molecular container assembly capable of controlling binding and release of its guest molecules: Reversible encapsulation of organic molecules in sodium ion complexed cucurbituril
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DOI：
10.1021/ja962071x
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发表时间：
1996-10-09
影响因子：
15
通讯作者：
Kim, K
中科院分区：
文献类型：
--
作者：
Jeon, YM;Kim, H;Kim, K
分子容器是一种刚性中空的有机主体化合物，其内部空腔大到足以容纳小的客体分子，是超分子化学的一个引人注目的发展。它们通常具有大环结构，具有允许客人进出的各种大小的开口。Rebek及其同事最近的出色工作2表明，自互补分子可以二聚形成球形胶囊，其中包裹着小分子或原子。此外，客体的包封和释放可以通过改变介质的酸度来控制。2c然而，没有其他容器分子已经证明在环境温度下其客体分子的这种可逆包封和释放，这将是分子容器在用于药物的受控释放时的重要优点。为了这个目标，可以设想客体分子的结合和释放通过阻断和开放分子容器的入口来控制，客体分子通过该入口进出。在这里，我们提出了第一个例子的分子容器组件能够控制其客体分子的结合和释放的这一原则。
Molecular containers, 1 rigid hollow organic host compounds whose interior cavities are large enough to accommodate small guest molecules, are one of the fascinating developments in supramolecular chemistry. They usually have macrocyclic structures with openings of various sizes that permit entrance and exit of the guest. Recent elegant work2 by Rebek and coworkers demonstrated that self-complementary molecules can dimerize to form spherical capsules in which small molecules or atoms are encapsulated. Moreover, the encapsulation and release of the guest can be controlled by change in the acidity of the medium. 2c However, no other container molecules have demonstrated such reversible encapsulation and release of their guest molecules at ambient temperatures, which will be an important virtue of molecular containers when they are used in controlled release of drugs. To this goal one can envision the binding and release of guest molecules being controlled by blocking and unblocking an entrance of a molecular container, through which guest molecules go in and out. Here we present the first example of molecular container assemblies capable of controlling the binding and release of its guest molecules by this principle.