Structural bases of Fc gamma R functions.
Structural bases of Fc gamma R functions.
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DOI：
10.3109/08830189709045701
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发表时间：
1997-01-01
影响因子：
5
通讯作者：
Daeron, M
中科院分区：
文献类型：
--
作者：
Daeron, M
这篇综述描述了决定 Fc gamma R 触发的生物活性的结构，并解释了 IgG 抗体在生理学和病理学中的细胞介导功能。 Fc gamma R 的结合特异性和亲和力主要取决于其免疫球蛋白样胞外域中的 IgG 结合结构。然而，结合也受到与多链 Fc gamma R 相关的亚基的影响。Fc gamma RIIB 家族分子特有的效应子和调节胞质内序列决定了这些受体的内化特性。基于免疫受体酪氨酸的激活基序 (ITAM) 是 Fc gamma R 和参与抗原识别的其他受体共享的胞质内效应序列，可触发细胞激活和内化。基于免疫受体酪氨酸的抑制基序 (ITIM) 是胞质内序列，由 Fc gamma RIIB 和越来越多的负辅助受体共享，这些负辅助受体通过 ITAM 承载受体负向调节细胞激活。总而言之，这些结构使 IgG 抗体能够在免疫反应过程中发挥各种精细调节的生物效应。
This review describes structures which determine the biological activities triggered by Fc gamma R and account for the cell-mediated functions of IgG antibodies in physiology and pathology. The binding specificity and affinity of Fc gamma R depend primarily on IgG-binding structures, in their immunoglobulin-like extracellular domains. Binding is however also influenced by subunits that associate to multichain Fc gamma R. Effector and regulatory intracytoplasmic sequences that are unique to molecules of the Fc gamma RIIB family determine the internalization properties of these receptors. Immunoreceptor Tyrosine-based Activation Motifs (ITAMs) are intracytoplasmic effector sequences shared by Fc gamma R and other receptors involved in the recognition of antigen, which trigger cell activation and internalization. Immunoreceptor Tyrosine-based Inhibition Motifs (ITIMs) are intracytoplasmic sequences, shared by Fc gamma RIIB and a growing number of negative coreceptors which negatively regulate cell activation via ITAM-bearing receptors. Altogether, these structures enable IgG antibodies to exert a variety of finely tuned biological effects during the immune response.