S100B protein concentrations in cord blood: correlations with gestational age in term and preterm deliveries.
S100B protein concentrations in cord blood: correlations with gestational age in term and preterm deliveries.
复制标题
脐带血中 S100B 蛋白浓度：与足月和早产胎龄的相关性。
DOI：
10.1093/clinchem/46.7.998
复制
发表时间：
2000
影响因子：
9.3
通讯作者：
Fabrizio Michetti
中科院分区：
文献类型：
--
作者：
D. Gazzolo;P. Vinesi;E. Marinoni;R. Iorio;M. Marras;M. Lituania;P. Bruschettini;Fabrizio Michetti
S100B是EF-Hand家族的一种酸性钙结合蛋白，集中在神经系统，主要定位于神经胶质细胞(1)。尽管已经提出了许多假说，但它的生物学作用仍然存在争议，但它在生物液中的出现已被证明是大脑窘迫的可靠指标。
我们研究了正常早产和足月分娩中妊娠晚期脐血S100B浓度与胎龄的关系。
我们调查了58例连续单胎生理性妊娠的妇女(足月30例，早产28例)，子宫胎盘血管血流频谱正常，分娩时间为27-42周。孕周由临床数据和妊娠早期超声扫描确定。根据Campbell和Thoms(3)的正常值，以及出生后根据我们的人口标准对母亲的身高、体重、产次和新生儿性别进行校正后，根据我们的人口标准，出生后确认出生体重在第10至90厘米之间，通过存在超声征象(当双顶径和腹围在第10至90厘米之间)定义适当的生长。排除标准为多胎、宫内发育迟缓、妊娠期高血压、糖尿病和感染、胎儿畸形、染色体异常、围产期窒息和难产。
该研究方案得到了热那亚大学詹尼娜·加斯利尼儿童医院伦理委员会的批准；Parents…
S100B is an acidic calcium-binding protein of the EF-hand family concentrated in the nervous system, where it is located mainly in glial cells (1). Although many hypotheses have been formulated, its biological role is still debated, but its appearance in biological fluids has been shown to be a reliable index of brain distress (2).
We investigated the relationship between S100B concentrations in cord blood and gestational age in the third trimester of pregnancy in normal preterm and term deliveries.
We investigated 58 women with consecutive singleton physiological pregnancies (30 at term and 28 preterm), with normal flow velocimetry waveforms in the uteroplacental vessels, whose delivery was between 27 and 42 weeks of gestation. Gestational age was determined by clinical data and by a first-trimester ultrasound scan. Appropriate growth was defined by the presence of ultrasonographic signs (when biparietal diameter and abdominal circumference were between the 10th and 90th centiles) according to the normograms of Campbell and Thoms (3) and by postnatal confirmation of a birth weight between the 10th and 90th centiles according to our population standards after correction for the mother’s height, weight, and parity, and the sex of the newborn. Exclusion criteria were multiple pregnancies, intrauterine growth retardation, gestational hypertension, diabetes and infections, fetal malformations, chromosomal abnormalities, perinatal asphyxia, and dystocia.
The study protocol was approved by the Ethics Committee of the Giannina Gaslini Children’s Hospital, Genoa University; the parents …