Characterization and antibacterial properties of genipin-crosslinked chitosan/poly(ethylene glycol)/ZnO/Ag nanocomposites
Characterization and antibacterial properties of genipin-crosslinked chitosan/poly(ethylene glycol)/ZnO/Ag nanocomposites
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DOI：
10.1016/j.carbpol.2012.02.058
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发表时间：
2012-06-05
影响因子：
11.2
通讯作者：
Kim, Hyung-Il
中科院分区：
文献类型：
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作者：
Liu, Yangshuo;Kim, Hyung-Il
制备了由京尼平交联壳聚糖（GC）、聚乙二醇（PEG）、氧化锌（ZnO）和银（Ag）纳米颗粒组成的新型纳米复合材料，用于生物医学应用，作为伤口愈合材料。不同量的ZnO和Ag纳米颗粒分散在GC/PEG水凝胶基质中，没有严重的聚集。通过红外分析、X射线衍射和扫描电子显微镜研究了纳米复合材料的组成和ZnO纳米粒子对其物理化学性能的影响。GC/PEG/ZnO/Ag纳米复合材料表现出pH敏感的溶胀行为和改善的力学性能。测试了纳米复合膜对大肠杆菌的抗菌活性。绿脓杆菌、金黄色葡萄球菌和枯草芽孢杆菌。GC/PEG/ZnO/Ag复合膜的抗菌活性高于GC/PEG和GC/PEG/ZnO纳米复合膜。GC/PEG/ZnO/Ag复合膜作为创伤和烧伤敷料具有潜在的应用前景。(C)2012爱思唯尔有限公司保留所有权利。
Novel nanocomposites consisting of genipin-crosslinked chitosan (GC), poly(ethylene glycol) (PEG), zinc oxide (ZnO), and silver (Ag) nanoparticles were prepared for biomedical applications as the wound-healing materials. Various amounts of ZnO and Ag nanoparticles were dispersed in the GC/PEG hydrogel matrix without severe aggregation. The effects of composition and ZnO nanoparticles on the physicochemical properties of nanocomposite samples were evaluated by infrared analysis, X-ray diffraction, and scanning electron microscopy. GC/PEG/ZnO/Ag nanocomposite showed the pH-sensitive swelling behavior and the improved mechanical properties. The antibacterial activities of nanocomposite films were tested toward the bacterial species Escherichia coli. Pseudomonas aeruginosa, Staphylococcus aureus, and Bacillus subtilis. GC/PEG/ZnO/Ag composite films had higher antibacterial activities than GC/PEG and GC/PEG/ZnO nanocomposite films. GC/PEG/ZnO/Ag composite films have potential application as wound and burn dressings. (C) 2012 Elsevier Ltd. All rights reserved.