Pericardial Influences on Ventricular Filling in the Conscious Dog: An Analysis Based on Pericardial Pressure
Pericardial Influences on Ventricular Filling in the Conscious Dog: An Analysis Based on Pericardial Pressure
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心包对清醒狗心室充盈的影响：基于心包压力的分析
DOI：
10.1161/01.res.54.2.173
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发表时间：
1984
影响因子：
20.1
通讯作者：
J. Rankin
中科院分区：
文献类型：
--
作者：
G. S. Tyson;G. Maier;C. Olsen;J. Davis;J. Rankin
本实验观察了25只犬的正常心包对心功能的影响。植入脉冲传输超声换能器以测量多个心室尺寸。在心脏底部横向切开心包，并精确对合，以尽量减少对其特性的干扰。一周后，在清醒状态下研究犬，用匹配的微压计测量左心室、右心室、心包和胸膜压力。记录扩容前后的数据。绝对舒张末期心包压在呼吸周期中直接随胸膜压变化。跨心包压（心包胸膜压）随呼吸变化不大，与心动周期期间心室直径直接相关，峰值跨心包压均匀发生在心室末。容量输注后，标准化舒张末期短轴直径和左室跨壁压（左室-胸膜压）分别从对照状态的0.14 ± 0.01和9.5 mm Hg ± 1.0 mm Hg显著增加至容量负荷后的0.20 ± 0.01和19.3 mm Hg ± 1.2 mm Hg。舒张末期经心包压也从2.3 ± 0.5 mm Hg显著增加至4.1 ± 0.3 mm Hg，约占透壁左心室压的21%。当在植入后连续获得测量值时，经心包压力最初较高，但随着时间的推移而降低，可能是由于心包蠕动。容量负荷后，右心室舒张末期跨壁压平均为9.6 mm Hg，心包压占右心室压的42%。因此，心包抑制效应可能主要影响右心室充盈，并通过串联相互作用影响左心室。在正常清醒的犬中，经心包压在整个生理范围内保持较低，正常心包对左心室舒张充盈的直接影响似乎很小。
Twenty-five dogs were chronically instrumented to investigate the effects of the normal pericardium on cardiac function. Pulse-transit ultrasonic transducers were implanted to measure multiple ventricular dimensions. The pericardium was incised transversely at the base of the heart and precisely reapproximated, so as to disturb its characteristics minimally. One week later, the dogs were studied in the conscious state, and left ventricular, right ventricular, pericardial, and pleural pressures were measured with matched micromanometers. Data were recorded before and after blood volume expansion. Absolute end-diastolic pericardial pressure varied directly with pleural pressure during the respiratory cycle. Tran pericardial pressure (pericardial-pleural pressure) varied little with respiration and was related directly to ventricular diameter during the cardiac cycle with peak transpericardial pressure uniformly occurring at end-diastole. With volume infusion, normalized end-diastolic minor axis diameter and left ventricular transmural pressure (left ventricular-pleural pressure) increased significantly from 0.14 ± 0.01 and 9.5 mm Hg ± 1.0 mm Hg, respectively, in the control state to 0.20 ± 0.01 and 19.3 mm Hg ± 1.2 mm Hg after volume loading. End-diastolic transpericardial pressure also increased significantly from 2.3 ± 0.5 mm Hg to 4.1 ± 0.3 mm Hg, and represented approximately 21% of transmural left ventricular pressure. When measurements were obtained sequentially after implantation, transpericardial pressure was initially high but decreased with time, presumably due to pericardial creep. After volume loading, right ventricular end-diastolic transmural pressure averaged 9.6 mm Hg, and pericardial pressure constituted 42% of right ventricular pressure. Thus, pericardial restraining effects may predominantly influence right ventricular filling and affect the left ventricle through series interaction. In the normal conscious dog, transpericardial pressure remains low over the entire physiological range, and the direct influence of the normal pericardium on diastolic filling of the left ventricle appears to be minimal.
全身缺血对清醒狗左心室舒张特性的影响。
影响因子：
37.8
作者：
Visner,MS;Arentzen,CE;Parrish,DG;Larson,EV;O'Connor,MJ;Crumbley3rd,AJ;Bache,RJ;Anderson,RW
通讯作者：
Anderson,RW