Racial background is a determinant factor in the maintenance dosage of warfarin
Racial background is a determinant factor in the maintenance dosage of warfarin
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DOI：
10.1007/bf02983247
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发表时间：
2003-07-01
影响因子：
2.1
通讯作者：
Pang, KW
中科院分区：
文献类型：
--
作者：
Gan, GG;Teh, A;Pang, KW
华法林是一种常用的预防血栓栓塞症的药物。有报道表明，种族背景可能会影响华法林剂量要求。马来西亚是一个多种族的国家，有三个主要种族，马来人、华人和印度人。我们对100例患者进行了华法林稳定维持量的检查，国际标准化比率(INR)为2.0~3.5。我们发现，印度患者(n=19)平均华法林剂量为6.9 mg，中国患者(n=55)平均华法林剂量为3.6 mg，马来患者(n=26)平均华法林剂量为3.2 mg。结果表明，印度患者所需的华法林剂量显著高于其他2个种族患者(P
Warfarin is a drug commonly used in the prevention of thromboembolic events. There have been reports suggesting that racial background may influence warfarin dose requirements. Malaysia is a multiracial country in which there are 3 major races, Malay, Chinese, and Indian. We examined 100 patients from our hospital on stable maintenance doses of warfarin, with international normalized ratio (INR) of 2.0 to 3.5. We found that the mean warfarin dose for Indian patients (n = 19) was 6.9 mg, for Chinese patients (n = 55) was 3.6 mg, and for Malay patients (n = 26) was 3.2 mg. The results showed that the Indian patients required a statistically significantly higher warfarin dose than did patients of the other 2 races (P