Cephalotane-type C20 diterpenoids from Cephalotaxus fortunei var. alpina.
Cephalotane-type C20 diterpenoids from Cephalotaxus fortunei var. alpina.
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来自 Cephalotaxus Fortunei var. 的三尖杉烷型 C20 二萜类化合物。
DOI：
10.1039/d2ob01748b
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发表时间：
2022-11
影响因子：
3.2
通讯作者：
Jian-Min Yue
中科院分区：
文献类型：
--
作者：
Zhan-Peng Ge;Bin Zhou;Flavia M Zimbres;Reagan S Haney;Qun-Fang Liu;Yan Wu;Maria B Cassera;Jin-Xin Zhao;Jian-Min Yue
从三尖杉种子中分离得到17个新的三尖杉烷型二萜化合物，FortalidesA-Q(1-17)和5个已知类似物。阿尔皮纳。它们的结构通过广泛的光谱方法以及电子圆二色谱(ECD)和X射线结晶学数据分析确定。一些菌株表现出了首次在头孢烷型二萜类化合物中发现的特殊结构特征，例如在14和15中出现了7-氧双环[4.1.1辛烷部分]，在9中出现了3-OH和Me-19的顺式排列。此外，本研究还对这些化合物的抗疟原虫活性进行了评价。
Seventeen new cephalotane-type diterpenoids, fortalides A-Q (1-17), along with five known analogues, were isolated from the seeds of Cephalotaxus fortunei var. alpina. Their structures were determined by extensive spectroscopic methods, as well as electronic circular dichroism (ECD) and X-ray crystallographic data analyses. Some isolates exhibited unusual structural features that were first found in cephalotane-type diterpenoids, such as the occurrence of the 7-oxabicyclo[4.1.1octane moiety in 14 and 15 and the cis-arrangement of 3-OH and Me-19 in 9. Besides, the antiplasmodial activity of these compounds was evaluated in this study.