Comparability of retinal nerve fiber layer thickness measurements of optical coherence tomography instruments
Comparability of retinal nerve fiber layer thickness measurements of optical coherence tomography instruments
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DOI：
10.1167/iovs.04-1000
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发表时间：
2005-04-01
影响因子：
4.4
通讯作者：
Weinreb, RN
中科院分区：
文献类型：
--
作者：
Bourne, RRA;Medeiros, FA;Weinreb, RN
目的。比较两种眼相干断层扫描（OCT）仪器（OCT 2000和Stratus OCT； Carl Zeiss Meditec, Dublin， CA）对视网膜神经纤维层（RNFL）的测量结果，并比较它们的诊断精度。在同一天连续对139名受试者进行成像（3 x 3.4 mm直径的圆形扫描）。35例患者因图像质量差而被排除。比较两种仪器测量的RNFL厚度，并采用受试者工作特征（ROC）曲线确定诊断精度。从104名参与者（28名开角型青光眼，40名疑似青光眼，36名健康受试者）中随机选择一只眼睛进行分析。OCT 2000的RNFL厚度测量结果普遍比Stratus OCT更厚。66名（65%）受试者的RNFL厚度差异在20 μ m以内，25名（25%）受试者的RNFL厚度差异在10 μ m（仪器的分辨率极限）以内。应用校正因子对OCT 2000测量结果进行预测，在75%的眼睛中，Stratus OCT RNFL厚度在观察测量值的10 μ m以内。对于两种仪器，最高的ROC曲线区域（更好地区分青光眼和正常眼睛）位于下扇形。Stratus OCT对RNFL整体厚度的鉴别优于OCT 2000 （P = 0.043）。利用本研究计算的校正因子，OCT 2000测量的RNFL厚度可以近似于Stratus OCT测量的厚度。然而，仍然存在相当大的可变性，超出了仪器本身所能提供的分辨率限制。因此，使用这些近似的仪器之间的比较应谨慎解释。
PURPOSE. To compare retinal nerve fiber layer (RNFL) measurements between two ocular coherence tomography (OCT) instruments ( OCT 2000 and Stratus OCT; Carl Zeiss Meditec, Dublin, CA) and compare their diagnostic precision.METHODS. One hundred thirty-nine consecutive subjects were imaged ( 3 x 3.4-mm diameter circular scans) on the same day with each instrument. Thirty-five patients were excluded due to poor-quality images. RNFL thicknesses measured by the two instruments were compared, and receiver operating characteristic (ROC) curves were used to determine diagnostic precision.RESULTS. A randomly selected eye of each of 104 participants ( 28 with open-angle glaucoma, 40 with suspected glaucoma, and 36 healthy subjects) was analyzed. RNFL thickness measurements generally were thicker with OCT 2000 than with Stratus OCT. The difference in global RNFL thickness between instruments was within 20 mu m in 66 (65%) of subjects and within 10 mu m ( the instrument's limit of resolution) in 25 (25%) subjects. Application of a correction factor to OCT 2000 measurements predicted Stratus OCT RNFL thickness within 10 mu m of the observed measurement in 75% of the eyes. For both instruments, highest ROC curve areas ( better discrimination between glaucomatous and normal eyes) were found in the inferior sector. Discrimination using global RNFL thickness was better with Stratus OCT than OCT 2000 ( P = 0.043).CONCLUSIONS. RNFL thickness measurements measured by OCT 2000 can be approximated to measurements made by Stratus OCT using correction factors calculated by this study. However, there remains considerable variability that exceeds the limits of resolution afforded by the instruments themselves. Therefore comparisons between instruments using these approximations should be interpreted with caution.