Stabilization of liquid interface and control of two-phase confluence and separation in glass microchips by utilizing octadecylsilane modification of microchannels
Stabilization of liquid interface and control of two-phase confluence and separation in glass microchips by utilizing octadecylsilane modification of microchannels
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DOI：
10.1021/ac011038c
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发表时间：
2002-04-01
影响因子：
7.4
通讯作者：
Kitamori, T
中科院分区：
文献类型：
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作者：
Hibara, A;Nonaka, M;Kitamori, T
我们在玻璃微芯片中演示了液/液和气/液两相交叉流。在顶部玻璃板上制作了 250 微米宽的用于水相流动的微通道。然后，作为利用表面能差实现稳定相汇合和分离的一种方式，在底部玻璃板上制作了250μm宽的有机相（或气相）流动微通道，并通过十八烷基硅烷（ODS）基团对通道壁进行化学改性。顶板和底板仅通过压力密封。设计了微通道图案，使得两相在直微通道的交叉点处接触。用光学显微镜观察交叉点。结果表明，微通道壁的 ODS 改性明显提高了两种流体之间界面的稳定性。测量了流体之间的压差，水和硝基苯的界面在+300 Pa至-200 Pa的压差范围内保持稳定。还估计了逆流配置中的压降，实现逆流所需的压差小于允许的压力范围。最后，我们讨论了使用这种方法的优点。
We demonstrated a liquid/liquid and a gas/liquid two-phase crossing flow in glass microchips. A 250-mum-wide microchannel for aqueous-phase flow was fabricated on a top glass plate. Then, as a way to utilize the surface energy difference for stable phase confluence and separation, a 250-mum-wide microchannel for organic-phase (or gas-phase) flow was fabricated on a bottom glass plate and the wall was chemically modified by octadecylsilane (ODS) group. The top and bottom plates were sealed only by pressure. A microchannel pattern was designed so that the two phases made contact at the crossing point of the straight microchannels. The crossing point was observed with an optical microscope. Results showed that the ODS modification of the microchannel wall clearly improved stability of the interface between the two fluids. Pressure difference between fluids was measured and the interface of water and nitrobenzene was stable for the pressure difference from +300 Pa to -200 Pa. The pressure drop in a countercurrent flow configuration was also estimated, and the pressure difference required to realize the countercurrent flow was less than the allowable pressure range. Finally, we discussed the advantages of utilizing this approach.