Hide, shield and strike back: how HIV-infected cells avoid immune eradication
Hide, shield and strike back: how HIV-infected cells avoid immune eradication
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DOI：
10.1038/nri998
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发表时间：
2003-02
影响因子：
100.3
通讯作者：
B. Peterlin;D. Trono
中科院分区：
文献类型：
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作者：
B. Peterlin;D. Trono
引起慢性感染的病毒可以逃避免疫反应。HIV是这类病原体的原型。它不仅会迅速突变，使其表面成分难以通过中和抗体进入，而且还会产生细胞藏身处，建立前病毒潜伏期，去除细胞表面受体并破坏免疫效应物以逃避根除。更好地理解这些战略可能会导致在防治艾滋病的斗争中采取新的办法。
Viruses that induce chronic infections can evade immune responses. HIV is a prototype of this class of pathogen. Not only does it mutate rapidly and make its surface components difficult to access by neutralizing antibodies, but it also creates cellular hideouts, establishes proviral latency, removes cell-surface receptors and destroys immune effectors to escape eradication. A better understanding of these strategies might lead to new approaches in the fight against AIDS.