Association between BDNF Val66Met genotype and episodic memory
Association between BDNF Val66Met genotype and episodic memory
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DOI：
10.1002/ajmg.b.30150
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发表时间：
2005-04-05
影响因子：
2.8
通讯作者：
Collier, DA
中科院分区：
文献类型：
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作者：
Dempster, E;Toulopoulou, T;Collier, DA
脑源性神经营养因子（BDNF）的val(66)met多态性与情景记忆的变异性有关[伊根等人，2003]。为了重复这一发现，我们对来自莫兹利家族研究的206人（92名患有精神分裂症或相关疾病，114名未患病亲属）进行了BDNF val(66)met多态性的基因分型。我们使用韦氏记忆量表修订版（WMS - R），通过逻辑记忆的WMS延迟得分与基因型之间的回归分析（校正年龄、性别和智商），分析了这种多态性对情景记忆的影响。我们发现met(66)等位基因在WMS延迟测量中得分较低（R² = 0.014，P = 0.09），但不显著。当分别对病例和未患病亲属进行分析时，met66仅在亲属中与WMS延迟测量的较低得分相关（R² = 0.077，P = 0.01），这与先前的研究结果一致。© 2005威利 - 利斯公司
The val(66) met polymorphism of brain derived neurotrophic factor (BDNF) has been associated with variability in episodic memory [Egan et al., 2003]. In an attempt to replicate this finding, we genotyped 206 individuals (92 affected with schizophrenia or a related disorder and 114 unaffected relatives) from the Maudsley Family Study for the BDNF val(66) met polymorphism. We analyzed the effect of this polymorphism on episodic memory using the Wechsler Memory Scale, revised version (WMS-R) by regression analysis between the WMS delayed score of logical memory and genotype (corrected for age, sex, and IQ). We found the met(66) allele conferred a lower score on the WMS delayed measure (R-2=0.014 P=0.09), which was not significant. When cases and unaffected relatives were analyzed separately, met66 was associated with a lower score on the WMS delayed measure in the relatives only (R-2=0.077 P=0.01), which is consistent with previous findings. C 2005 Wiley-Liss, Inc.