Centralized obesity and cardiovascular disease risk in Mexican Americans.
Centralized obesity and cardiovascular disease risk in Mexican Americans.
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墨西哥裔美国人的集中性肥胖和心血管疾病风险。
DOI：
10.1093/oxfordjournals.aje.a114544
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发表时间：
1987
影响因子：
5
通讯作者：
Schull,WJ
中科院分区：
文献类型：
--
作者：
Reichley,KB;Mueller,WH;Hanis,CL;Joos,SK;Tulloch,BR;Barton,S;Schull,WJ
在1981-1983年在德克萨斯州斯塔尔县研究的墨西哥裔美国成年人样本中，研究了体脂分布模式与心血管疾病风险变量（高密度脂蛋白胆固醇、总胆固醇、舒张压和收缩压以及空腹血糖水平）之间的关系。在样本中，所有糖尿病患者都被排除在外，以观察集中式肥胖是否有独立于糖尿病的心血管疾病风险。通过对包括上肢、下肢和躯干区域在内的五个皮褶测量值进行主成分分析，确定了集中体脂肪分布的一个组成部分。将集中肥胖与人群中四个亚组（年轻和年长成年男性和女性）的全身性（外周）肥胖和非肥胖对照进行比较。所有心血管风险变量的平均值都指向一个方向，表明集中式肥胖者的风险显著高于非肥胖者（特别是高密度脂蛋白胆固醇、总胆固醇和血糖水平）。全身性肥胖与集中性肥胖的区别在于血糖水平明显较低，在其他变量中往往介于集中性肥胖和非肥胖对照组之间。数据证实，集中式肥胖（由皮肤褶积测量的线性组合定义）与腰臀围比（腰臀围比）在描述身材因素方面的作用相同，该因素会增加肥胖者患心血管疾病的风险，而与临床糖尿病状态无关。
The association between body fat distribution patterns and cardiovascular disease risk variables (high density lipoprotein (HDL) cholesterol, total cholesterol, diastolic and systolic blood pressures, and fasting blood glucose levels) was sought in a sample of Mexican American adults who were studied during 1981–1983 in Starr County, Texas. In the sample, all diabetics were excluded to see whether centralized obesity carried any risk for cardiovascular disease independent of diabetes. A component of centralized body fat distribution was identified through the use of principal components analysis of five skinfold measurements, which included the upper and lower extremities and trunk areas. The centralized obese were compared with generalized (peripheral) obese and nonobese controls in four subgroups of the population: younger and older adult males and females. The means of all cardiovascular risk variables were in a direction indicating that the centralized obese were significantly at greater risk than nonobese controls (in particular, HDL cholesterol, total cholesterol, and blood glucose levels). The generalized obese differed from the centralized obese in having significantly lower blood glucose levels, and tended to be intermediate between centralized obese and nonobese controls in the other variables. The data confirm that centralized obesity as defined by a linear combination of skinfold measures works in the same way as the waist-to-hip circumference ratio in describing a body build factor which heightens the risk of cardiovascular disease in the obese independent of the clinical diabetic state.