Cellular cytotoxicity against autologous hepatocytes in alcoholic liver disease.
Cellular cytotoxicity against autologous hepatocytes in alcoholic liver disease.
复制标题
酒精性肝病中针对自体肝细胞的细胞毒性。
DOI：
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发表时间：
2008
期刊：
影响因子：
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通讯作者：
K. Büschenfelde
中科院分区：
文献类型：
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作者：
T. Poralla;T. Hütteroth;K. Büschenfelde
We tested lymphocyte cytotoxicity against autologous hepatocytes in patients with alcoholic liver disease (ALD). The following cytotoxicity values were found (mean +/- SEM): alcohol-induced steatosis with or without fibrosis 16.5 +/- 2% (n = 29), alcoholic cirrhosis 28 +/- 4% (n = 13), controls with normal liver histology or minimal changes 6 +/- 2% (n = 11). The differences were statistically significant (both forms of ALD versus controls p less than 0.005). T-cell as well as non-T-cell-enriched lymphocyte fractions showed increased cytotoxicity in ALD. We did not observe a correlation between cellular cytotoxicity and the degree of biochemical or histological alterations within the groups tested. Thus, our study demonstrating enhanced cellular cytotoxicity against autologous hepatocytes in ALD further supports the hypothesis that cellular immune reactions are involved in the pathogenesis of ALD, especially of alcoholic cirrhosis.
狒狒酒精性脂肪肝中单核细胞的细胞毒性和肝细胞的脆弱性。
DOI：
10.1111/j.1600-0676.1981.tb00042.x
发表时间：
1981
期刊：
Liver
影响因子：
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作者：
Lue,SL;Paronetto,F;Lieber,CS
通讯作者：
Lieber,CS