Bioinspired biliverdin/silk fibroin hydrogel for antiglioma photothermal therapy and wound healing.
Bioinspired biliverdin/silk fibroin hydrogel for antiglioma photothermal therapy and wound healing.
复制标题
用于抗神经胶质瘤光热治疗和伤口愈合的仿生胆绿素/丝素蛋白水凝胶
DOI：
10.7150/thno.47682
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发表时间：
2020
期刊：
影响因子：
12.4
通讯作者：
Zhao YZ
中科院分区：
文献类型：
--
作者：
Yao Q;Lan QH;Jiang X;Du CC;Zhai YY;Shen X;Xu HL;Xiao J;Kou L;Zhao YZ
依据：光热疗法利用光吸收剂在近红外（NIR）照射下产生热量，用于热肿瘤消融。然而，NIR照射可能会由于光吸收剂的泄漏而损伤邻近组织，并且治疗后的残留材料可能会阻碍局部愈合过程。具有光热性质和有效促愈合能力的双功能水凝胶为解决这一问题提供了可行的选择。研究方法：在这项研究中，我们开发了一种生物启发的绿色水凝胶（BVSF），将生物产品胆绿素整合到天然衍生的丝素蛋白基质中，用于抗胶质瘤光热治疗和伤口愈合。结果如下：BVSF水凝胶在近红外辐射下具有良好的可控光热活性，并在体外和体内均产生有效的肿瘤消融。此外，BVSF水凝胶在体外和体内均发挥抗炎作用，并在全层缺损大鼠模型中刺激血管生成和伤口愈合。结论：总体而言，该概念验证研究旨在确定使用全天然绿色制剂进行光热治疗和治疗后护理的可行性和可靠性。
Rationale: Photothermal therapy employs the photoabsorbers to generate heat under the near-infrared (NIR) irradiation for thermal tumor ablation. However, NIR irradiation might damage the adjacent tissue due to the leakage of the photoabsorbers and the residual materials after treatment might hinder the local healing process. A bifunctional hydrogel that holds both photothermal property and potent pro-healing ability provides a viable option to resolve this issue. Methods: In this study, we developed a bioinspired green hydrogel (BVSF) with the integration of bioproduct biliverdin into natural derived silk fibroin matrix for antiglioma photothermal therapy and wound healing. Results: The BVSF hydrogel possessed excellent and controllable photothermal activity under NIR irradiation and resulted in effective tumor ablation both in vitro and in vivo. Additionally, the BVSF hydrogel exerted anti-inflammatory effects both in vitro and in vivo, and stimulated angiogenesis and wound healing in a full-thickness defect rat model. Conclusion: Overall, this proof-of-concept study was aimed to determine the feasibility and reliability of using an all-natural green formulation for photothermal therapy and post-treatment care.