A central role for thymic emigrants in peripheral T cell homeostasis
A central role for thymic emigrants in peripheral T cell homeostasis
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DOI：
10.1073/pnas.96.17.9787
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发表时间：
1999-08-17
影响因子：
11.1
通讯作者：
Boyd, RL
中科院分区：
文献类型：
--
作者：
Berzins, SP;Godfrey, DI;Boyd, RL
在胸腺移行细胞初始接种后，T细胞库的稳态调节被认为完全发生在外周。在这里，我们报告的程度胸腺移民直接影响的数量和外周血T细胞的CD 4/CD 8的比例。我们证明了由2、6或9个胸腺叶的植入引起的T细胞池大小的增加几乎与前3周从这些移植物中输出的移民数量完全相关，无论移植物已经存在多久。增加的程度支持胸腺出口后3周的概念，其中移民T细胞免于外周T细胞稳态。这种明显的排斥最近胸腺移民从利基为基础的调节外周T细胞数量，确保整个成年生活的剧目营业额，并提供了一个直接的和以前未被认识到的作用，胸腺在外周T细胞的稳态调节的基础。
After initial seeding by thymic emigrants, homeostatic regulation of the T cell pool has been thought to occur entirely within the periphery. Here we report that the degree of thymic emigration directly affects the number and the CD4/CD8 ratio of peripheral T cells. We demonstrate that the increase in T cell pool size caused by the engraftment of 2, 6, or 9 thymic lobes correlates almost exactly with the number of emigrants exported from those grafts in the previous 3 weeks, regardless of how long the graft has been in place. The extent of the increase supports the concept of a 3-week period after thymic export in which emigrant T cells are exempt from peripheral T cell homeostasis. This apparent exclusion of recent thymic emigrants from the niche-based regulation of peripheral T cell numbers ensures repertoire turnover throughout adult life and provides the basis of a direct and previously unrecognized role for the thymus in the regulation of peripheral T cell homeostasis.